2. Antibody-drug Conjugate/ADC Related PROTAC
  3. ADC Linker PROTAC Linkers
  4. Amino-Tri-(carboxyethoxymethyl)-methane

Amino-Tri-(carboxyethoxymethyl)-methane is a cleavable PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Amino-Tri-(carboxyethoxymethyl)-methan is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

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Amino-Tri-(carboxyethoxymethyl)-methane Chemical Structure

Amino-Tri-(carboxyethoxymethyl)-methane Chemical Structure

CAS No. : 174362-95-9

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Based on 1 publication(s) in Google Scholar

Other Forms of Amino-Tri-(carboxyethoxymethyl)-methane:

Amino-Tri-(carboxyethoxymethyl)-methane Related Antibodies

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Description

Amino-Tri-(carboxyethoxymethyl)-methane is a cleavable PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Amino-Tri-(carboxyethoxymethyl)-methan is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[2].

IC50 & Target[1][2]

PEGs

 

Cleavable Linker

 

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Amino-Tri-(carboxyethoxymethyl)-methane Related Antibodies
Molecular Weight

337.32

Formula

C13H23NO9
CAS No.
Appearance

Solid-Liquid Mixture

Color

Colorless to off-white

SMILES

NC(COCCC(O)=O)(COCCC(O)=O)COCCC(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Purity & Documentation
References
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Amino-Tri-(carboxyethoxymethyl)-methane Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Amino-Tri-(carboxyethoxymethyl)-methane174362-95-9ADC LinkerPROTAC LinkersAntibody-drug conjugates linkerPEGADClinkerPROTACcleavableInhibitorinhibitorinhibit

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