1. Antibody-drug Conjugate/ADC Related
    PROTAC
  2. ADC Linker
    PROTAC Linker
  3. Amino-Tri-(carboxyethoxymethyl)-methane

Amino-Tri-(carboxyethoxymethyl)-methane 

Cat. No.: HY-117519
Handling Instructions

Amino-Tri-(carboxyethoxymethyl)-methane is a cleavable PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Amino-Tri-(carboxyethoxymethyl)-methan is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

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Amino-Tri-(carboxyethoxymethyl)-methane Chemical Structure

Amino-Tri-(carboxyethoxymethyl)-methane Chemical Structure

CAS No. : 174362-95-9

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Description

Amino-Tri-(carboxyethoxymethyl)-methane is a cleavable PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Amino-Tri-(carboxyethoxymethyl)-methan is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[2].

IC50 & Target[1][2]

PEGs

 

Cleavable

 

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].

Molecular Weight

337.32

Formula

C₁₃H₂₃NO₉

CAS No.

174362-95-9

SMILES

NC(COCCC(O)=O)(COCCC(O)=O)COCCC(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Amino-Tri-(carboxyethoxymethyl)-methaneADC LinkerPROTAC LinkerAntibody-drug conjugates linkerPEGADClinkerPROTACcleavableInhibitorinhibitorinhibit

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Product name:
Amino-Tri-(carboxyethoxymethyl)-methane
Cat. No.:
HY-117519
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