Amino-Tri-(carboxyethoxymethyl)-methane hydrochloride
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Amino-Tri-(carboxyethoxymethyl)-methane hydrochloride is a cleavable PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Amino-Tri-(carboxyethoxymethyl)-methan hydrochloride is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
For research use only. We do not sell to patients.
- Purity: 97.0%
- CAS No.: 1416771-72-6
- Formula: C13H24ClNO9
- Molecular Weight:373.78
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Storage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
In Vitro
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1416771-72-6
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Appearance Solid
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Molecular Weight 373.78
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Formula C13H24ClNO9
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Color White to off-white
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SMILES
O=C(CCOCC(COCCC(O)=O)(COCCC(O)=O)N)O.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (267.54 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (270 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.6754 mL | 13.3769 mL | 26.7537 mL | 66.8843 mL |
| 5 mM | 0.5351 mL | 2.6754 mL | 5.3507 mL | 13.3769 mL | |
| 10 mM | 0.2675 mL | 1.3377 mL | 2.6754 mL | 6.6884 mL | |
| 15 mM | 0.1784 mL | 0.8918 mL | 1.7836 mL | 4.4590 mL | |
| 20 mM | 0.1338 mL | 0.6688 mL | 1.3377 mL | 3.3442 mL | |
| 25 mM | 0.1070 mL | 0.5351 mL | 1.0701 mL | 2.6754 mL | |
| 30 mM | 0.0892 mL | 0.4459 mL | 0.8918 mL | 2.2295 mL | |
| 40 mM | 0.0669 mL | 0.3344 mL | 0.6688 mL | 1.6721 mL | |
| 50 mM | 0.0535 mL | 0.2675 mL | 0.5351 mL | 1.3377 mL | |
| 60 mM | 0.0446 mL | 0.2229 mL | 0.4459 mL | 1.1147 mL | |
| 80 mM | 0.0334 mL | 0.1672 mL | 0.3344 mL | 0.8361 mL | |
| 100 mM | 0.0268 mL | 0.1338 mL | 0.2675 mL | 0.6688 mL |
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