Amino-Tri-(carboxyethoxymethyl)-methane hydrochloride

Name: Amino-Tri-(carboxyethoxymethyl)-methane hydrochloride
Brand: MedChemExpress
SKU: HY-117519A
Rating: 4.5 (1 reviews)

Cat. No.: HY-117519A Purity: ≥97.0%: FAQs
Data Sheet SDS COA Handling Instructions

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Amino-Tri-(carboxyethoxymethyl)-methane hydrochloride is a cleavable PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Amino-Tri-(carboxyethoxymethyl)-methan hydrochloride is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

Amino-Tri-(carboxyethoxymethyl)-methane hydrochloride Chemical Structure

CAS No. : 1416771-72-6

Size	Price	Stock	Quantity
25 mg	USD 45	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 70	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 112	Get quote	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of Amino-Tri-(carboxyethoxymethyl)-methane hydrochloride:

Amino-Tri-(carboxyethoxymethyl)-methane In-stock

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•Related Small Molecules:

•Related Proteins:

View All ADC Linker Isoform Specific Products:

View All Isoforms

Cleavable Linker Non-cleavable Linker Acid Cleavable Linker Disulfide Cleavable Linker Protease Cleavable Linker Glycosidase Cleavable Linker Phosphatase Cleavable Linker

View All PROTAC Linkers Isoform Specific Products:

View All Isoforms

PEG Linkers Alkyl-Chain Linkers Alkyl/ether Linkers

Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker^[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

373.78

Formula

C₁₃H₂₄ClNO₉

CAS No.

1416771-72-6

Appearance

Solid

Color

White to off-white

SMILES

O=C(CCOCC(COCCC(O)=O)(COCCC(O)=O)N)O.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (267.54 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.6754 mL	13.3769 mL	26.7537 mL
5 mM	0.5351 mL	2.6754 mL	5.3507 mL
10 mM	0.2675 mL	1.3377 mL	2.6754 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥97.0%

Select Batch:

Data Sheet (270 KB) SDS (0 KB)

COA (247 KB)

Handling Instructions (2659 KB)

References

[1]. Markus Ribbert, et al. Self coupling recombinant antibody fusion proteins. WO2009013359A2.

[2]. David Margulies, et al. Fluorescent molecular sensor for targeting changes in protein surfaces, and methods of use thereof. WO2015166491A2.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.6754 mL	13.3769 mL	26.7537 mL	66.8843 mL
	5 mM	0.5351 mL	2.6754 mL	5.3507 mL	13.3769 mL
	10 mM	0.2675 mL	1.3377 mL	2.6754 mL	6.6884 mL
	15 mM	0.1784 mL	0.8918 mL	1.7836 mL	4.4590 mL
	20 mM	0.1338 mL	0.6688 mL	1.3377 mL	3.3442 mL
	25 mM	0.1070 mL	0.5351 mL	1.0701 mL	2.6754 mL
	30 mM	0.0892 mL	0.4459 mL	0.8918 mL	2.2295 mL
	40 mM	0.0669 mL	0.3344 mL	0.6688 mL	1.6721 mL
	50 mM	0.0535 mL	0.2675 mL	0.5351 mL	1.3377 mL
	60 mM	0.0446 mL	0.2229 mL	0.4459 mL	1.1147 mL
	80 mM	0.0334 mL	0.1672 mL	0.3344 mL	0.8361 mL
	100 mM	0.0268 mL	0.1338 mL	0.2675 mL	0.6688 mL