2. Antibody-drug Conjugate/ADC Related
  3. ADC Linker
  4. Boc-NH-C6-Br

Boc-NH-C6-Br is a non-cleavable linker used for antibody-drug conjugates (ADC).

For research use only. We do not sell to patients.

Boc-NH-C6-Br Chemical Structure

Boc-NH-C6-Br Chemical Structure

CAS No. : 142356-33-0

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Based on 1 publication(s) in Google Scholar

Boc-NH-C6-Br Related Antibodies

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Description

Boc-NH-C6-Br is a non-cleavable linker used for antibody-drug conjugates (ADC)[1].

IC50 & Target[1]

Non-cleavable Linker

 

Molecular Weight

280.20

Formula

C11H22BrNO2
CAS No.
Appearance

Solid-Liquid Mixture

Color

Colorless to off-white

SMILES

O=C(OC(C)(C)C)NCCCCCCBr
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 40 mg/mL (142.76 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5689 mL 17.8444 mL 35.6888 mL
5 mM 0.7138 mL 3.5689 mL 7.1378 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥98.0%

COA (241 KB) HNMR (112 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.5689 mL 17.8444 mL 35.6888 mL 89.2220 mL
5 mM 0.7138 mL 3.5689 mL 7.1378 mL 17.8444 mL
10 mM 0.3569 mL 1.7844 mL 3.5689 mL 8.9222 mL
15 mM 0.2379 mL 1.1896 mL 2.3793 mL 5.9481 mL
20 mM 0.1784 mL 0.8922 mL 1.7844 mL 4.4611 mL
25 mM 0.1428 mL 0.7138 mL 1.4276 mL 3.5689 mL
30 mM 0.1190 mL 0.5948 mL 1.1896 mL 2.9741 mL
40 mM 0.0892 mL 0.4461 mL 0.8922 mL 2.2305 mL
50 mM 0.0714 mL 0.3569 mL 0.7138 mL 1.7844 mL
60 mM 0.0595 mL 0.2974 mL 0.5948 mL 1.4870 mL
80 mM 0.0446 mL 0.2231 mL 0.4461 mL 1.1153 mL
100 mM 0.0357 mL 0.1784 mL 0.3569 mL 0.8922 mL
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Boc-NH-C6-Br Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Boc-NH-C6-Br142356-33-0ADC LinkerAntibody-drug conjugates linkerInhibitorinhibitorinhibit

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