DBCO-PEG4-VA-PABC-MMAE

Cat. No.: HY-176765 Purity: 98.94%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

DBCO-PEG4-VA-PABC-MMAE is a drug-linker conjugate for ADC. DBCO-PEG4-VA-PABC-MMAE consists of a tubulin inhibitor (MMAE) (HY-15162) and a cleavable linker (DBCO-PEG4-VA-PABC). DBCO-PEG4-VA-PABC-MMAE can be used for synthesis of ADC ABBV-400 (HY-171945).

For research use only. We do not sell to patients.

DBCO-PEG4-VA-PABC-MMAE Chemical Structure

CAS No. : 3049211-57-3

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Molecular Weight

1571.93

Formula

C₈₅H₁₂₂N₁₀O₁₈

CAS No.

3049211-57-3

Appearance

Solid

Color

White to off-white

SMILES

O=C(N1[C@](CCC1)([H])[C@H](OC)[C@@H](C)C(N[C@H](C)[C@H](C2=CC=CC=C2)O)=O)C[C@@H](OC)[C@H]([C@@H](C)CC)N(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)C(OCC(C=C3)=CC=C3NC([C@H](C)NC([C@H](C(C)C)NC(CCOCCOCCOCCOCCNC(CCC(N4C5=CC=CC=C5C#CC6=CC=CC=C6C4)=O)=O)=O)=O)=O)=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL (63.62 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.6362 mL	3.1808 mL	6.3616 mL
5 mM	0.1272 mL	0.6362 mL	1.2723 mL
10 mM	0.0636 mL	0.3181 mL	0.6362 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

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Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.94%

Select Batch:

Data Sheet (264 KB) SDS (252 KB)

COA (241 KB) HNMR (414 KB) RP-HPLC (219 KB) MS (71 KB)

Handling Instructions (2659 KB)

References

[1]. Hartley O, et al. Variant ligand conjugates for payload delivery. WO2024146707A1. 2024-07-11.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	0.6362 mL	3.1808 mL	6.3616 mL	15.9040 mL
	5 mM	0.1272 mL	0.6362 mL	1.2723 mL	3.1808 mL
	10 mM	0.0636 mL	0.3181 mL	0.6362 mL	1.5904 mL
	15 mM	0.0424 mL	0.2121 mL	0.4241 mL	1.0603 mL
	20 mM	0.0318 mL	0.1590 mL	0.3181 mL	0.7952 mL
	25 mM	0.0254 mL	0.1272 mL	0.2545 mL	0.6362 mL
	30 mM	0.0212 mL	0.1060 mL	0.2121 mL	0.5301 mL
	40 mM	0.0159 mL	0.0795 mL	0.1590 mL	0.3976 mL
	50 mM	0.0127 mL	0.0636 mL	0.1272 mL	0.3181 mL
	60 mM	0.0106 mL	0.0530 mL	0.1060 mL	0.2651 mL