TriOncoFAP-GlyPro-MMAE
TriOncoFAP-GlyPro-MMAE is a small molecule drug conjugate (SMDC) targeting fibroblast activation protein (FAP) with an IC50 of 13 pmol/L. TriOncoFAP-GlyPro-MMAE combines a FAP-targeting ligand (TriOnco), a cleavable glycine-proline linker, and a cytotoxic payload (MMAE).
For research use only. We do not sell to patients.
- Formula: C167H218F6N36O43S
- Molecular Weight:3563.79
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Chemical Information
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Molecular Weight 3563.79
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Formula C167H218F6N36O43S
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SMILES
O=C(NCCNC(CCOCC(COCCC(NCCNC(CCC(NC1=CC=CC2=C1N=CC=C2C(NCC(N3CC(C[C@H]3C#N)(F)F)=O)=O)=O)=O)=O)(COCCC(NCCNC(CCC(NC4=C(N=CC=C5C(NCC(N6CC(C[C@H]6C#N)(F)F)=O)=O)C5=CC=C4)=O)=O)=O)NC(CCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CSC7C(N(C(C7)=O)CCCCCC(NCC(N8[C@@H](CCC8)C(NC9=CC=C(C=C9)COC(N([C@H](C(N[C@H](C(N([C@H]([C@@H](CC(N%10[C@]([H])([C@@H]([C@H](C(N[C@@H]([C@@H](O)C%11=CC=CC=C%11)C)=O)C)OC)CCC%10)=O)OC)[C@H](CC)C)C)=O)C(C)C)=O)C(C)C)C)=O)=O)=O)=O)=O)C(O)=O)=O)CC(O)=O)=O)CCCCN)=O)CC(O)=O)=O)=O)=O)CCC(NC%12=CC=CC%13=C%12N=CC=C%13C(NCC(N%14[C@H](C#N)CC(C%14)(F)F)=O)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
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Cell Viability Determination by MTT Colorimetric Assay
The following protocol uses the MTT colorimetric assay as a classic literature-established method for assessing cell viability/metabolic activity in cultured mammalian cells. MTT[3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] is reduced by metabolically active cells to a colored formazan product; the amount of formazan is quantified spectrophotometrically and provides an indirect measure of metabolically active viable cells. Importantly, MTT reduction reflects cellular oxidoreductase/metabolic activity rather than an absolute direct count of living cells, so changes in cellular metabolism can alter the signal independently of cell number.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
TriOncoFAP-GlyPro-MMAE Related Classifications
HY-175353 Related Classifications
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