1. Antibody-drug Conjugate/ADC Related
    PROTAC
  2. ADC Linker
    PROTAC Linker
  3. TCO-PEG4-DBCO

TCO-PEG4-DBCO 

Cat. No.: HY-140310
Handling Instructions

TCO-PEG4-DBCO is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. TCO-PEG4-DBCO is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

For research use only. We do not sell to patients.

TCO-PEG4-DBCO Chemical Structure

TCO-PEG4-DBCO Chemical Structure

CAS No. : 1801863-88-6

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Description

TCO-PEG4-DBCO is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. TCO-PEG4-DBCO is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

IC50 & Target[1]

Cleavable

 

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

675.81

Formula

C₃₈H₄₉N₃O₈

CAS No.

1801863-88-6

SMILES

O=C(N1C2=CC=CC=C2C#CC3=CC=CC=C3C1)CCNC(CCOCCOCCOCCOCCNC(OC4CCC/C=C\CC4)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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  • Molarity Calculator

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

TCO-PEG4-DBCOADC LinkerPROTAC LinkerAntibody-drug conjugates linkerPEGPROTAClinkerE3ubiquitinligaseproteinnon-cleavableADCantibody-drugconjugatesInhibitorinhibitorinhibit

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Product Name:
TCO-PEG4-DBCO
Cat. No.:
HY-140310
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