PC SPDP-NHS carbonate ester
Based on 1 Customer Validation
PC SPDP-NHS carbonate ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
For research use only. We do not sell to patients.
- Purity: 95.0%
- CAS No.: 2279944-61-3
- Formula: C25H28N4O10S2
- Molecular Weight:608.64
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Storage:
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Disulfide Cleavable Linker |
Cleavable Linker |
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2279944-61-3
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Appearance Solid
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Molecular Weight 608.64
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Formula C25H28N4O10S2
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Color White to off-white
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SMILES
O=C(CCCOC1=CC([N+]([O-])=O)=C(C(C)OC(ON2C(CCC2=O)=O)=O)C=C1OC)NCCSSC3=NC=CC=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Solvent & Solubility
Chloroform : 50 mg/mL (82.15 mM; Need ultrasonic and warming)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (269 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| Chloroform | 1 mM | 1.6430 mL | 8.2150 mL | 16.4301 mL | 41.0752 mL |
| 5 mM | 0.3286 mL | 1.6430 mL | 3.2860 mL | 8.2150 mL | |
| 10 mM | 0.1643 mL | 0.8215 mL | 1.6430 mL | 4.1075 mL | |
| 15 mM | 0.1095 mL | 0.5477 mL | 1.0953 mL | 2.7383 mL | |
| 20 mM | 0.0822 mL | 0.4108 mL | 0.8215 mL | 2.0538 mL | |
| 25 mM | 0.0657 mL | 0.3286 mL | 0.6572 mL | 1.6430 mL | |
| 30 mM | 0.0548 mL | 0.2738 mL | 0.5477 mL | 1.3692 mL | |
| 40 mM | 0.0411 mL | 0.2054 mL | 0.4108 mL | 1.0269 mL | |
| 50 mM | 0.0329 mL | 0.1643 mL | 0.3286 mL | 0.8215 mL | |
| 60 mM | 0.0274 mL | 0.1369 mL | 0.2738 mL | 0.6846 mL | |
| 80 mM | 0.0205 mL | 0.1027 mL | 0.2054 mL | 0.5134 mL |
PC SPDP-NHS carbonate ester Related Classifications
HY-140138 Related Classifications
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