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Mecbotamab

(Synonyms: BA301)
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Based on 1 Customer Validation

Mecbotamab is a humanized IgG1-κ antibody targeting to AXL receptor tyrosine kinase (AXL). Mecbotamab can serves as a conditionally active biologic (CAB), which can be conjugated with MMAE (HY-15162) via a cleavable linker, to form ADC Mecbotamab vedotin (BA3011).

For research use only. We do not sell to patients.

  • Purity: 99.83%
  • CAS No.: 2460400-28-4
  • Molecular Weight:145.126 kDa
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Mecbotamab
  • Experimental Validation Results for Mecbotamab
  • Experimental Validation Results for Mecbotamab
  • Mecbotamab Chemical Structure
    Mecbotamab Chemical Structure
CAS No.: 2460400-28-4
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Mecbotamab Product Recommendations:

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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Assay Types
  • 1/16

    Human IgG1 kappa

  • 1/16

    Immobilized AXL Protein, Human (HEK293, His, HY-P74407) can bind Mecbotamab. The EC50 for this effect is 3.315 ng/mL.

  • 1/16

    Flow cytometric analysis of 1X106 A549 cells with Mecbotamab (HY-P9988, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Fluor 488-conjugated AffiniPure Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • Mecbotamab Chemical Structure
    1/16
  • Mecbotamab
  • Immobilized AXL Protein, Human (HEK293, His, HY-P74407) can bind Mecbotamab. The EC50 for this effect is 3.315 ng/mL.
  • Flow cytometric analysis of 1X106 A549 cells with Mecbotamab (HY-P9988, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Fluor 488-conjugated AffiniPure Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).