DBM-GGFG-NH-O-CO-Exatecan
Based on 1 Customer Validation
DBM-GGFG-NH-O-CO-Exatecan (Example 4, Compound 14) is a conjugate of an ADC drug toxin molecule and a linker. DBM-GGFG-NH-O-CO-Exatecan is a complete antibody-drug conjugate intermediate that integrates a potent camptothecin-based toxin, a cleavable peptide linker (GGFG), and a reactive terminus that can directly conjugate to antibodies.
For research use only. We do not sell to patients.
- Purity: 96.83%
- CAS No.: 2769152-95-4
- Formula: C52H54Br2FN9O13
- Molecular Weight:1191.84
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Storage:
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Drug-Linker Conjugates for ADC Isoforms
More
Biological Activity
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Camptothecins |
DBM-GGFG-NH-O-CO-Exatecan can directly yield antibody-drug conjugate b after incubation with antibody M30-H1-L4P[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2769152-95-4
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Appearance Solid
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Molecular Weight 1191.84
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Formula C52H54Br2FN9O13
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Color White to light yellow
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SMILES
O=C(C(Br)=C(C1=O)Br)N1CCCCCC(NCC(NCC(N[C@@H](CC2=CC=CC=C2)C(NCC(NCOCC(N[C@@H]3C4=C5C(C(N6C5)=CC([C@](O)(C(OC7)=O)CC)=C7C6=O)=NC8=CC(F)=C(C)C(CC3)=C84)=O)=O)=O)=O)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 50 mg/mL (41.95 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.8390 mL | 4.1952 mL | 8.3904 mL | 20.9760 mL |
| 5 mM | 0.1678 mL | 0.8390 mL | 1.6781 mL | 4.1952 mL | |
| 10 mM | 0.0839 mL | 0.4195 mL | 0.8390 mL | 2.0976 mL | |
| 15 mM | 0.0559 mL | 0.2797 mL | 0.5594 mL | 1.3984 mL | |
| 20 mM | 0.0420 mL | 0.2098 mL | 0.4195 mL | 1.0488 mL | |
| 25 mM | 0.0336 mL | 0.1678 mL | 0.3356 mL | 0.8390 mL | |
| 30 mM | 0.0280 mL | 0.1398 mL | 0.2797 mL | 0.6992 mL | |
| 40 mM | 0.0210 mL | 0.1049 mL | 0.2098 mL | 0.5244 mL |
DBM-GGFG-NH-O-CO-Exatecan Related Classifications
HY-160807 Related Classifications
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