2. Antibody-drug Conjugate/ADC Related
  3. Drug-Linker Conjugates for ADC
  4. DBM-MMAF

DBM-MMAF is a agent-linker conjugate composed of a potent antitubulin agent MMAF and a linker DBM to make antibody agent conjugate (ADC).

For research use only. We do not sell to patients.

DBM-MMAF Chemical Structure

DBM-MMAF Chemical Structure

CAS No. : 1810001-93-4

Size Price Stock Quantity
5 mg USD 450 In-stock
10 mg USD 800 In-stock
25 mg USD 1650 In-stock
50 mg USD 2550 In-stock
100 mg USD 3800 In-stock
200 mg   Get quote  
500 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

DBM-MMAF Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE DBM-MMAF

View All Drug-Linker Conjugates for ADC Isoform Specific Products:

View All Isoforms
Auristatin Camptothecins Daunorubicins/Doxorubicins Duocarmycins Maytansinoids Pyrrolobenzodiazepines Traditional Cytotoxic Agents

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

DBM-MMAF is a agent-linker conjugate composed of a potent antitubulin agent MMAF and a linker DBM to make antibody agent conjugate (ADC)[1].

IC50 & Target[1]

Auristatin

 

Molecular Weight

1082.95

Formula

C49H74Br2N6O11
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

C[C@@H](C(N[C@H](C(O)=O)CC1=CC=CC=C1)=O)[C@H]([C@@](CCC2)([H])N2C(C[C@@H](OC)[C@H]([C@@H](C)CC)N(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)C(CCCCCN(C3=O)C(C(Br)=C3Br)=O)=O)=O)=O)=O)OC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 200 mg/mL (184.68 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9234 mL 4.6170 mL 9.2340 mL
5 mM 0.1847 mL 0.9234 mL 1.8468 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.9234 mL 4.6170 mL 9.2340 mL 23.0851 mL
5 mM 0.1847 mL 0.9234 mL 1.8468 mL 4.6170 mL
10 mM 0.0923 mL 0.4617 mL 0.9234 mL 2.3085 mL
15 mM 0.0616 mL 0.3078 mL 0.6156 mL 1.5390 mL
20 mM 0.0462 mL 0.2309 mL 0.4617 mL 1.1543 mL
25 mM 0.0369 mL 0.1847 mL 0.3694 mL 0.9234 mL
30 mM 0.0308 mL 0.1539 mL 0.3078 mL 0.7695 mL
40 mM 0.0231 mL 0.1154 mL 0.2309 mL 0.5771 mL
50 mM 0.0185 mL 0.0923 mL 0.1847 mL 0.4617 mL
60 mM 0.0154 mL 0.0770 mL 0.1539 mL 0.3848 mL
80 mM 0.0115 mL 0.0577 mL 0.1154 mL 0.2886 mL
100 mM 0.0092 mL 0.0462 mL 0.0923 mL 0.2309 mL
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DBM-MMAF Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DBM-MMAF1810001-93-4Drug-Linker Conjugates for ADCDBMMMAFADCantitubulinInhibitorinhibitorinhibit

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