Fmoc-Phe-Lys(Trt)-PAB
Based on 1 Customer Validation
Fmoc-Phe-Lys(Trt)-PAB is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
For research use only. We do not sell to patients.
- CAS No.: 1116085-98-3
- Formula: C56H54N4O5
- Molecular Weight:863.05
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Storage:
Store at room temperature, keep dry and cool.
In solvent -80°C, 1 year , -20°C, 6 months
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Protease Cleavable Linker |
Cleavable Linker |
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1116085-98-3
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Appearance Solid
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Molecular Weight 863.05
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Formula C56H54N4O5
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Color White to off-white
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SMILES
O=C(N)[C@H](CCCCNC(C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3)N(C([C@H](CC4=CC=CC=C4)NC(OCC5C6=C(C7=C5C=CC=C7)C=CC=C6)=O)=O)C8=CC=C(CO)C=C8
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Store at room temperature, keep dry and cool
In solvent -80°C 1 year -20°C 6 months
Solvent & Solubility
DMSO : 100 mg/mL (115.87 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.1587 mL | 5.7934 mL | 11.5868 mL | 28.9670 mL |
| 5 mM | 0.2317 mL | 1.1587 mL | 2.3174 mL | 5.7934 mL | |
| 10 mM | 0.1159 mL | 0.5793 mL | 1.1587 mL | 2.8967 mL | |
| 15 mM | 0.0772 mL | 0.3862 mL | 0.7725 mL | 1.9311 mL | |
| 20 mM | 0.0579 mL | 0.2897 mL | 0.5793 mL | 1.4484 mL | |
| 25 mM | 0.0463 mL | 0.2317 mL | 0.4635 mL | 1.1587 mL | |
| 30 mM | 0.0386 mL | 0.1931 mL | 0.3862 mL | 0.9656 mL | |
| 40 mM | 0.0290 mL | 0.1448 mL | 0.2897 mL | 0.7242 mL | |
| 50 mM | 0.0232 mL | 0.1159 mL | 0.2317 mL | 0.5793 mL | |
| 60 mM | 0.0193 mL | 0.0966 mL | 0.1931 mL | 0.4828 mL | |
| 80 mM | 0.0145 mL | 0.0724 mL | 0.1448 mL | 0.3621 mL | |
| 100 mM | 0.0116 mL | 0.0579 mL | 0.1159 mL | 0.2897 mL |
Fmoc-Phe-Lys(Trt)-PAB Related Classifications
HY-136107 Related Classifications
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