Fmoc-Phe-Lys(Trt)-PAB

Name: Fmoc-Phe-Lys(Trt)-PAB
Brand: MedChemExpress
SKU: HY-136107
Rating: 4.5 (1 reviews)

Cat. No.: HY-136107: Data Sheet
SDS
Handling Instructions
FAQs
Technical Support

Fmoc-Phe-Lys(Trt)-PAB is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

For research use only. We do not sell to patients.

Fmoc-Phe-Lys(Trt)-PAB Chemical Structure

CAS No. : 1116085-98-3

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
250 mg	Get quote	Estimated Time of Arrival: December 31
500 mg	Get quote
1 g	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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View All Isoforms

Cleavable Linker Non-cleavable Linker Acid Cleavable Linker Disulfide Cleavable Linker Protease Cleavable Linker Glycosidase Cleavable Linker Phosphatase Cleavable Linker

Biological Activity
Purity & Documentation
References
Customer Review

Description

Fmoc-Phe-Lys(Trt)-PAB is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)^[1].

IC₅₀ & Target

Protease Cleavable Linker

Cleavable Linker

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

863.05

Formula

C₅₆H₅₄N₄O₅

CAS No.

1116085-98-3

Appearance

Solid

Color

White to off-white

SMILES

O=C(N)[C@H](CCCCNC(C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3)N(C([C@H](CC4=CC=CC=C4)NC(OCC5C6=C(C7=C5C=CC=C7)C=CC=C6)=O)=O)C8=CC=C(CO)C=C8

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Store at room temperature, keep dry and cool

In solvent	-80°C	1 year
	-20°C	6 months

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (115.87 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.1587 mL	5.7934 mL	11.5868 mL
5 mM	0.2317 mL	1.1587 mL	2.3174 mL
10 mM	0.1159 mL	0.5793 mL	1.1587 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Data Sheet (274 KB) SDS (252 KB) Handling Instructions (2659 KB)

References

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.1587 mL	5.7934 mL	11.5868 mL	28.9670 mL
	5 mM	0.2317 mL	1.1587 mL	2.3174 mL	5.7934 mL
	10 mM	0.1159 mL	0.5793 mL	1.1587 mL	2.8967 mL
	15 mM	0.0772 mL	0.3862 mL	0.7725 mL	1.9311 mL
	20 mM	0.0579 mL	0.2897 mL	0.5793 mL	1.4484 mL
	25 mM	0.0463 mL	0.2317 mL	0.4635 mL	1.1587 mL
	30 mM	0.0386 mL	0.1931 mL	0.3862 mL	0.9656 mL
	40 mM	0.0290 mL	0.1448 mL	0.2897 mL	0.7242 mL
	50 mM	0.0232 mL	0.1159 mL	0.2317 mL	0.5793 mL
	60 mM	0.0193 mL	0.0966 mL	0.1931 mL	0.4828 mL
	80 mM	0.0145 mL	0.0724 mL	0.1448 mL	0.3621 mL
	100 mM	0.0116 mL	0.0579 mL	0.1159 mL	0.2897 mL