2. Antibody-drug Conjugate/ADC Related PROTAC
  3. ADC Linker PROTAC Linkers
  4. Mal-PEG2-acid

Mal-PEG2-acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Mal-PEG2-acid can be conjugated to Tubulysin (HY-128914) and its derivative cytotoxic molecule. Mal-PEG2-acid is also a PROTAC linker that can be used in the synthesis of PROTACs.

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Mal-PEG2-acid Chemical Structure

Mal-PEG2-acid Chemical Structure

CAS No. : 1374666-32-6

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Based on 1 publication(s) in Google Scholar

Mal-PEG2-acid Related Antibodies

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Description

Mal-PEG2-acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Mal-PEG2-acid can be conjugated to Tubulysin (HY-128914) and its derivative cytotoxic molecule[1]. Mal-PEG2-acid is also a PROTAC linker that can be used in the synthesis of PROTACs.

IC50 & Target

Non-cleavable Linker

 

PEGs

 

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Mal-PEG2-acid Related Antibodies
Molecular Weight

257.24

Formula

C11H15NO6
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(O)CCOCCOCCN1C(C=CC1=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation

Purity: 99.62%

SDS (393 KB)

COA (245 KB) HNMR (133 KB) RP-HPLC (223 KB) LCMS (98 KB)

Handling Instructions (2659 KB)
References
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Mal-PEG2-acid Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mal-PEG2-acid1374666-32-6ADC LinkerPROTAC LinkersAntibody-drug conjugates linkerADClinkerprotacTubulysinInhibitorinhibitorinhibit

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Mal-PEG2-acid
Cat. No.:
HY-130442
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SAFETY DATA SHEET (SDS)

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