1. Antibody-drug Conjugate/ADC Related
  2. Drug-Linker Conjugates for ADC
  3. NC5-VC-PAB-MMAE

NC5-VC-PAB-MMAE  (Synonyms: SuO-Glu-Val-Cit-PAB-MMAE)

Cat. No.: HY-130989 Purity: 99.20%
COA Handling Instructions

NC5-VC-PAB-MMAE (SuO-Glu-Val-Cit-PAB-MMAE) consists a cleavable ADC linker (SuO-Glu-Val-Cit-PAB) and a potent tubulin inhibitor (MMAE). NC5-VC-PAB-MMAE can be used in the synthesis of antibody-drug conjugates (ADCs).

For research use only. We do not sell to patients.

NC5-VC-PAB-MMAE Chemical Structure

NC5-VC-PAB-MMAE Chemical Structure

CAS No. : 1895916-24-1

Size Price Stock Quantity
1 mg USD 350 In-stock
5 mg USD 1050 In-stock
10 mg USD 1500 In-stock
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100 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

NC5-VC-PAB-MMAE (SuO-Glu-Val-Cit-PAB-MMAE) consists a cleavable ADC linker (SuO-Glu-Val-Cit-PAB) and a potent tubulin inhibitor (MMAE). NC5-VC-PAB-MMAE can be used in the synthesis of antibody-drug conjugates (ADCs)[1].

IC50 & Target

Auristatin

 

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

1334.60

Formula

C67H103N11O17

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC[C@H](C)[C@@H]([C@@H](CC(N1[C@@H](CCC1)[C@@H]([C@@H](C)C(N[C@H](C)[C@@H](O)C2=CC=CC=C2)=O)OC)=O)OC)N(C([C@H](C(C)C)NC([C@H](C(C)C)N(C(OCC3=CC=C(NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCCC(ON4C(CCC4=O)=O)=O)=O)=O)=O)C=C3)=O)C)=O)=O)C

Shipping

Shipping with dry ice.

Storage

-80°C, protect from light

*The compound is unstable in solutions, freshly prepared is recommended.

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (74.93 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.7493 mL 3.7464 mL 7.4929 mL
5 mM 0.1499 mL 0.7493 mL 1.4986 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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Volume (start)

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Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.20%

References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.7493 mL 3.7464 mL 7.4929 mL 18.7322 mL
5 mM 0.1499 mL 0.7493 mL 1.4986 mL 3.7464 mL
10 mM 0.0749 mL 0.3746 mL 0.7493 mL 1.8732 mL
15 mM 0.0500 mL 0.2498 mL 0.4995 mL 1.2488 mL
20 mM 0.0375 mL 0.1873 mL 0.3746 mL 0.9366 mL
25 mM 0.0300 mL 0.1499 mL 0.2997 mL 0.7493 mL
30 mM 0.0250 mL 0.1249 mL 0.2498 mL 0.6244 mL
40 mM 0.0187 mL 0.0937 mL 0.1873 mL 0.4683 mL
50 mM 0.0150 mL 0.0749 mL 0.1499 mL 0.3746 mL
60 mM 0.0125 mL 0.0624 mL 0.1249 mL 0.3122 mL
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
NC5-VC-PAB-MMAE
Cat. No.:
HY-130989
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