SuO-Glu-Val-Cit-PAB-MMAE-d8-1
Based on 1 Customer Validation
SuO-Glu-Val-Cit-PAB-MMAE-d8-1 (NHS-Glutarate-Val-Cit-PAB-MMAE-d8-1) is the deuterated-labeled SuO-Glu-Val-Cit-PAB-MMAE (HY-130989). SuO-Glu-Val-Cit-PAB-MMAE (NHS-Glutarate-Val-Cit-PAB-MMAE) consists a cleavable ADC linker (SuO-Glu-Val-Cit-PAB) and a potent tubulin inhibitor (MMAE). SuO-Glu-Val-Cit-PAB-MMAE can be used in the synthesis of antibody-drug conjugates (ADCs).
For research use only. We do not sell to patients.
- Formula: C67H95D8N11O17
- Molecular Weight:1342.65
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Storage:
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Drug-Linker Conjugates for ADC Isoforms
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Biological Activity
Description
In Vitro
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Application
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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Unlabeled CAS 1895916-24-1
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Appearance Solid
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Molecular Weight 1342.65
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Formula C67H95D8N11O17
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SMILES
O=C(N([C@@H]([C@@H](C)CC)[C@H](OC)CC(N1[C@H]([C@H](OC)[C@@H](C)C(N[C@H](C)[C@@H](O)C2=CC=CC=C2)=O)CCC1)=O)C)[C@@]([2H])(NC([C@@H](N(C(OCC3=CC=C(C=C3)NC([C@@H](NC([C@@H](NC(CCCC(ON4C(CCC4=O)=O)=O)=O)C(C)C)=O)CCCNC(N)=O)=O)=O)C)C(C)C)=O)C([2H])(C([2H])([2H])[2H])C([2H])([2H])[2H]
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Synonyms
NHS-Glutarate-Val-Cit-PAB-MMAE-d8-1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (74.48 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.7448 mL | 3.7240 mL | 7.4480 mL | 18.6199 mL |
| 5 mM | 0.1490 mL | 0.7448 mL | 1.4896 mL | 3.7240 mL | |
| 10 mM | 0.0745 mL | 0.3724 mL | 0.7448 mL | 1.8620 mL | |
| 15 mM | 0.0497 mL | 0.2483 mL | 0.4965 mL | 1.2413 mL | |
| 20 mM | 0.0372 mL | 0.1862 mL | 0.3724 mL | 0.9310 mL | |
| 25 mM | 0.0298 mL | 0.1490 mL | 0.2979 mL | 0.7448 mL | |
| 30 mM | 0.0248 mL | 0.1241 mL | 0.2483 mL | 0.6207 mL | |
| 40 mM | 0.0186 mL | 0.0931 mL | 0.1862 mL | 0.4655 mL | |
| 50 mM | 0.0149 mL | 0.0745 mL | 0.1490 mL | 0.3724 mL | |
| 60 mM | 0.0124 mL | 0.0621 mL | 0.1241 mL | 0.3103 mL |
SuO-Glu-Val-Cit-PAB-MMAE-d8-1 Related Classifications
HY-130989S1 Related Classifications
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