MethylCBI-azaindole-benzamide-MOM-Boc-ethylenediamine-D
Based on 1 Customer Validation
MethylCBI-azaindole-benzamide-MOM-Boc-ethylenediamine-D is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
For research use only. We do not sell to patients.
- Purity : 98.92%
- CAS No.: 2222445-87-4
- Formula: C44H51ClN6O10
- Molecular Weight:859.36
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
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Cleavable Linker |
In Vitro
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
Chemical Information
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CAS No. 2222445-87-4
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Appearance Solid
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Molecular Weight 859.36
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Formula C44H51ClN6O10
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Color White to light yellow
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SMILES
ClC[C@H]1C2=C(C=C(C3=CC=CC(C)=C32)OC(N(CCOCCO)CCN(C)C(OC(C)(C)C)=O)=O)N(C1)C(C4=CN(C=C(C=C5)NC(C6=CC=C(C=C6)OCOC)=O)C5=N4)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
In Vitro:
DMSO : 50 mg/mL (58.18 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 1.1637 mL | 5.8183 mL | 11.6366 mL | 29.0914 mL |
| 5 mM | 0.2327 mL | 1.1637 mL | 2.3273 mL | 5.8183 mL | |
| 10 mM | 0.1164 mL | 0.5818 mL | 1.1637 mL | 2.9091 mL | |
| 15 mM | 0.0776 mL | 0.3879 mL | 0.7758 mL | 1.9394 mL | |
| 20 mM | 0.0582 mL | 0.2909 mL | 0.5818 mL | 1.4546 mL | |
| 25 mM | 0.0465 mL | 0.2327 mL | 0.4655 mL | 1.1637 mL | |
| 30 mM | 0.0388 mL | 0.1939 mL | 0.3879 mL | 0.9697 mL | |
| 40 mM | 0.0291 mL | 0.1455 mL | 0.2909 mL | 0.7273 mL | |
| 50 mM | 0.0233 mL | 0.1164 mL | 0.2327 mL | 0.5818 mL |
MethylCBI-azaindole-benzamide-MOM-Boc-ethylenediamine-D Related Classifications
HY-145488 Related Classifications
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