1. PROTAC
    Antibody-drug Conjugate/ADC Related
  2. PROTAC Linker
    ADC Linker
  3. Aminoethyl-SS-ethylalcohol

Aminoethyl-SS-ethylalcohol 

Cat. No.: HY-117409
Handling Instructions

Aminoethyl-SS-ethylalcohol (Compound 3) is an Alkyl-Chain-based PROTAC linker can be used in the synthesis of PROTACs. Aminoethyl-SS-ethylalcohol is also a glutathione cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

For research use only. We do not sell to patients.

Aminoethyl-SS-ethylalcohol Chemical Structure

Aminoethyl-SS-ethylalcohol Chemical Structure

CAS No. : 15579-01-8

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Description

Aminoethyl-SS-ethylalcohol (Compound 3) is an Alkyl-Chain-based PROTAC linker can be used in the synthesis of PROTACs[1]. Aminoethyl-SS-ethylalcohol is also a glutathione cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2].

IC50 & Target[1][2]

Alkyl-Chain

 

Cleavable

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2].

Molecular Weight

153.27

Formula

C₄H₁₁NOS₂

CAS No.

15579-01-8

SMILES

NCCSSCCO

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

Aminoethyl-SS-ethylalcoholPROTAC LinkerADC LinkerAntibody-drug conjugates linkerPROTACAlkyl-Chain-basedlinkerADCcleavableInhibitorinhibitorinhibit

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Product name:
Aminoethyl-SS-ethylalcohol
Cat. No.:
HY-117409
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