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Cat. No.: HY-130490

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Biotin-bis-amido-SS-NHS

Name: Biotin-bis-amido-SS-NHS
Brand: MedChemExpress
SKU: HY-130490
Price: 60.00 USD
Availability: InStock
Rating: 5 (1 reviews)

Biotin-bis-amido-SS-NHS is an Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

CAS No.: 142439-92-7
Formula: C₂₂H₃₃N₅O₇S₃
Molecular Weight:575.72

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (263 KB)

Biotin-bis-amido-SS-NHS Chemical Structure

CAS No.: 142439-92-7

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

Biotin-bis-amido-SS-NHS is an Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs.

IC₅₀ & Target^[1]

Alkyl/ether

All PROTAC Linkers Isoforms :

In Vitro

Biotin-bis-amido-SS-NHS is a long arm biotin containing disulfide bond, and the compound can be applied to biochemistry detection field, reduce the influence of steric effect, improve the sensitivity of detection^[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein.
PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 142439-92-7
Molecular Weight 575.72
Formula C₂₂H₃₃N₅O₇S₃
SMILES

O=C(NCCNC(CCSSCCC(ON1C(CCC1=O)=O)=O)=O)CCCC[C@@H]2SC[C@]([C@]2([H])N3)([H])NC3=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (263 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Liyanping, et al. A kind of long arm biotin containing disulfide bond and preparation method thereof. Patent CN107383054A.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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Biotin-bis-amido-SS-NHS

Sulfo-NHS-SS-Biotin sodium

Biotin-C5-NHS Ester

DBCO-S-S-PEG3-biotin

NHS-SS-biotin

Biotinyl tyramide

Sulfosuccinimidyl-6-(biotinamido)hexanoate sodium

Dde Biotin-PEG4-DBCO

Boc-Cystamine

Azide-C2-SS-C2-biotin

PC Biotin-PEG3-azide

PC Biotin-PEG3-NHS ester

Boc-NH-ethyl-SS-propionic acid

All PROTAC Linkers Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Bioz

Biotin-bis-amido-SS-NHS

Sulfo-NHS-SS-Biotin sodium

Biotin-C5-NHS Ester

DBCO-S-S-PEG3-biotin

NHS-SS-biotin

Biotinyl tyramide

Sulfosuccinimidyl-6-(biotinamido)hexanoate sodium

Dde Biotin-PEG4-DBCO

Boc-Cystamine

Azide-C2-SS-C2-biotin

PC Biotin-PEG3-azide

PC Biotin-PEG3-NHS ester

Boc-NH-ethyl-SS-propionic acid

All PROTAC Linkers Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Biotin-bis-amido-SS-NHS Related Classifications

HY-130490 Related Classifications

Bioz