PC Mal-NHS carbonate ester
PC Mal-NHS carbonate ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
For research use only. We do not sell to patients.
- CAS No.: 1408057-91-9
- Formula: C24H26N4O12
- Molecular Weight:562.48
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cleavable Linker |
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1408057-91-9
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Appearance Solid
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Molecular Weight 562.48
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Formula C24H26N4O12
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Color White to off-white
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SMILES
O=C(ON1C(CCC1=O)=O)OC(C2=CC(OC)=C(OCCCC(NCCN3C(C=CC3=O)=O)=O)C=C2[N+]([O-])=O)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (177.78 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (270 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.7778 mL | 8.8892 mL | 17.7784 mL | 44.4460 mL |
| 5 mM | 0.3556 mL | 1.7778 mL | 3.5557 mL | 8.8892 mL | |
| 10 mM | 0.1778 mL | 0.8889 mL | 1.7778 mL | 4.4446 mL | |
| 15 mM | 0.1185 mL | 0.5926 mL | 1.1852 mL | 2.9631 mL | |
| 20 mM | 0.0889 mL | 0.4445 mL | 0.8889 mL | 2.2223 mL | |
| 25 mM | 0.0711 mL | 0.3556 mL | 0.7111 mL | 1.7778 mL | |
| 30 mM | 0.0593 mL | 0.2963 mL | 0.5926 mL | 1.4815 mL | |
| 40 mM | 0.0444 mL | 0.2222 mL | 0.4445 mL | 1.1112 mL | |
| 50 mM | 0.0356 mL | 0.1778 mL | 0.3556 mL | 0.8889 mL | |
| 60 mM | 0.0296 mL | 0.1482 mL | 0.2963 mL | 0.7408 mL | |
| 80 mM | 0.0222 mL | 0.1111 mL | 0.2222 mL | 0.5556 mL | |
| 100 mM | 0.0178 mL | 0.0889 mL | 0.1778 mL | 0.4445 mL |
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