2. Antibody-drug Conjugate/ADC Related
  3. ADC Linker
  4. Mal-PEG4-Val-Cit-PAB

Mal-PEG4-Val-Cit-PAB is a cleavable ADC linker containing a Maleimide group. Mal-PEG4-Val-Cit-PAB is used in the synthesis of antibody-drug conjugates (ADCs).

For research use only. We do not sell to patients.

Mal-PEG4-Val-Cit-PAB Chemical Structure

Mal-PEG4-Val-Cit-PAB Chemical Structure

CAS No. : 1949793-41-2

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Based on 1 publication(s) in Google Scholar

Mal-PEG4-Val-Cit-PAB Related Antibodies

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Description

Mal-PEG4-Val-Cit-PAB is a cleavable ADC linker containing a Maleimide group. Mal-PEG4-Val-Cit-PAB is used in the synthesis of antibody-drug conjugates (ADCs)[1].

IC50 & Target[1]

Cleavable Linker

 

Protease Cleavable Linker

 

Molecular Weight

777.86

Formula

C36H55N7O12
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OCC1=CC=C(NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCOCCOCCOCCOCCNC(CCN2C(C=CC2=O)=O)=O)=O)=O)=O)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 83.33 mg/mL (107.13 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.2856 mL 6.4279 mL 12.8558 mL
5 mM 0.2571 mL 1.2856 mL 2.5712 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.2856 mL 6.4279 mL 12.8558 mL 32.1395 mL
5 mM 0.2571 mL 1.2856 mL 2.5712 mL 6.4279 mL
10 mM 0.1286 mL 0.6428 mL 1.2856 mL 3.2139 mL
15 mM 0.0857 mL 0.4285 mL 0.8571 mL 2.1426 mL
20 mM 0.0643 mL 0.3214 mL 0.6428 mL 1.6070 mL
25 mM 0.0514 mL 0.2571 mL 0.5142 mL 1.2856 mL
30 mM 0.0429 mL 0.2143 mL 0.4285 mL 1.0713 mL
40 mM 0.0321 mL 0.1607 mL 0.3214 mL 0.8035 mL
50 mM 0.0257 mL 0.1286 mL 0.2571 mL 0.6428 mL
60 mM 0.0214 mL 0.1071 mL 0.2143 mL 0.5357 mL
80 mM 0.0161 mL 0.0803 mL 0.1607 mL 0.4017 mL
100 mM 0.0129 mL 0.0643 mL 0.1286 mL 0.3214 mL
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Mal-PEG4-Val-Cit-PAB Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mal-PEG4-Val-Cit-PAB1949793-41-2ADC LinkerAntibody-drug conjugates linkerInhibitorinhibitorinhibit

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