2. Antibody-drug Conjugate/ADC Related
  3. ADC Linker
  4. Fmoc-Glu-(Boc)-Val-Cit-PAB-PNP

Fmoc-Glu-(Boc)-Val-Cit-PAB-PNP 

Cat. No.: HY-136154 Purity: 98.42%
COA Handling Instructions

Fmoc-Glu-(Boc)-Val-Cit-PAB-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

For research use only. We do not sell to patients.

Fmoc-Glu-(Boc)-Val-Cit-PAB-PNP Chemical Structure

Fmoc-Glu-(Boc)-Val-Cit-PAB-PNP Chemical Structure

Size Price Stock Quantity
Free Sample (0.1 - 0.5 mg)   Apply Now  
25 mg USD 600 In-stock
50 mg USD 960 In-stock
100 mg USD 1550 In-stock
200 mg   Get quote  
500 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

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Based on 1 publication(s) in Google Scholar

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  • Purity & Documentation

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Description

Fmoc-Glu-(Boc)-Val-Cit-PAB-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

IC50 & Target

Protease Cleavable

 

Cleavable

 

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

952.02

Appearance

Solid

Formula

C49H57N7O13
SMILES

O=C(OC1=CC=C([N+]([O-])=O)C=C1)OCC2=CC=C(NC([[email protected]](CCCNC(N)=O)NC([[email protected]](C(C)C)NC([[email protected]](CCC(OC(C)(C)C)=O)NC(OCC3C4=C(C5=C3C=CC=C5)C=CC=C4)=O)=O)=O)=O)C=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Solvent & Solubility
In Vitro: 

DMSO : 180 mg/mL (189.07 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.0504 mL 5.2520 mL 10.5040 mL
5 mM 0.2101 mL 1.0504 mL 2.1008 mL
10 mM 0.1050 mL 0.5252 mL 1.0504 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 4.5 mg/mL (4.73 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Fmoc-Glu-(Boc)-Val-Cit-PAB-PNPADC LinkerAntibody-drug conjugates linkerInhibitorinhibitorinhibit

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Fmoc-Glu-(Boc)-Val-Cit-PAB-PNP
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