Fmoc-Glu-(Boc)-Val-Cit-PAB-PNP
Based on 1 Customer Validation
Fmoc-Glu-(Boc)-Val-Cit-PAB-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
For research use only. We do not sell to patients.
- Purity: 96.67%
- Formula: C49H57N7O13
- Molecular Weight:952.02
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Storage:
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Protease Cleavable Linker |
Cleavable Linker |
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Appearance Solid
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Molecular Weight 952.02
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Formula C49H57N7O13
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Color Off-white to light yellow
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SMILES
O=C(OC1=CC=C([N+]([O-])=O)C=C1)OCC2=CC=C(NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC([C@H](CCC(OC(C)(C)C)=O)NC(OCC3C4=C(C5=C3C=CC=C5)C=CC=C4)=O)=O)=O)=O)C=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Solvent & Solubility
DMSO : 180 mg/mL (189.07 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (271 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 1.0504 mL | 5.2520 mL | 10.5040 mL | 26.2600 mL |
| 5 mM | 0.2101 mL | 1.0504 mL | 2.1008 mL | 5.2520 mL | |
| 10 mM | 0.1050 mL | 0.5252 mL | 1.0504 mL | 2.6260 mL | |
| 15 mM | 0.0700 mL | 0.3501 mL | 0.7003 mL | 1.7507 mL | |
| 20 mM | 0.0525 mL | 0.2626 mL | 0.5252 mL | 1.3130 mL | |
| 25 mM | 0.0420 mL | 0.2101 mL | 0.4202 mL | 1.0504 mL | |
| 30 mM | 0.0350 mL | 0.1751 mL | 0.3501 mL | 0.8753 mL | |
| 40 mM | 0.0263 mL | 0.1313 mL | 0.2626 mL | 0.6565 mL | |
| 50 mM | 0.0210 mL | 0.1050 mL | 0.2101 mL | 0.5252 mL | |
| 60 mM | 0.0175 mL | 0.0875 mL | 0.1751 mL | 0.4377 mL | |
| 80 mM | 0.0131 mL | 0.0656 mL | 0.1313 mL | 0.3282 mL | |
| 100 mM | 0.0105 mL | 0.0525 mL | 0.1050 mL | 0.2626 mL |
Fmoc-Glu-(Boc)-Val-Cit-PAB-PNP Related Classifications
HY-136154 Related Classifications
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