2. Antibody-drug Conjugate/ADC Related
  3. ADC Linker
  4. Fmoc-Ala-Ala-PAB

Fmoc-Ala-Ala-PAB is a cleavable ADC linker. Fmoc-Ala-Ala-PAB can be used in the synthesis of antibody-drug conjugates (ADCs).

For research use only. We do not sell to patients.

Fmoc-Ala-Ala-PAB Chemical Structure

Fmoc-Ala-Ala-PAB Chemical Structure

CAS No. : 1384263-83-5

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Based on 1 publication(s) in Google Scholar

Fmoc-Ala-Ala-PAB Related Antibodies

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Description

Fmoc-Ala-Ala-PAB is a cleavable ADC linker. Fmoc-Ala-Ala-PAB can be used in the synthesis of antibody-drug conjugates (ADCs)[1].

IC50 & Target[1]

Cleavable Linker

 

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Fmoc-Ala-Ala-PAB Related Antibodies
Molecular Weight

487.55

Formula

C28H29N3O5
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

OCC(C=C1)=CC=C1NC([C@H](C)NC([C@H](C)NC(OCC2C3=CC=CC=C3C4=CC=CC=C42)=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (256.38 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0511 mL 10.2554 mL 20.5107 mL
5 mM 0.4102 mL 2.0511 mL 4.1021 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.86%

COA (247 KB) HNMR (145 KB) LCMS (94 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0511 mL 10.2554 mL 20.5107 mL 51.2768 mL
5 mM 0.4102 mL 2.0511 mL 4.1021 mL 10.2554 mL
10 mM 0.2051 mL 1.0255 mL 2.0511 mL 5.1277 mL
15 mM 0.1367 mL 0.6837 mL 1.3674 mL 3.4185 mL
20 mM 0.1026 mL 0.5128 mL 1.0255 mL 2.5638 mL
25 mM 0.0820 mL 0.4102 mL 0.8204 mL 2.0511 mL
30 mM 0.0684 mL 0.3418 mL 0.6837 mL 1.7092 mL
40 mM 0.0513 mL 0.2564 mL 0.5128 mL 1.2819 mL
50 mM 0.0410 mL 0.2051 mL 0.4102 mL 1.0255 mL
60 mM 0.0342 mL 0.1709 mL 0.3418 mL 0.8546 mL
80 mM 0.0256 mL 0.1282 mL 0.2564 mL 0.6410 mL
100 mM 0.0205 mL 0.1026 mL 0.2051 mL 0.5128 mL
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Fmoc-Ala-Ala-PAB Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fmoc-Ala-Ala-PAB1384263-83-5ADC LinkerAntibody-drug conjugates linkerADC linkercleavableInhibitorinhibitorinhibit

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