1. Antibody-drug Conjugate/ADC Related PROTAC
  2. ADC Linker PROTAC Linkers
  3. cis-4-Hydroxy-L-proline hydrochloride

cis-4-Hydroxy-L-proline hydrochloride 

Cat. No.: HY-W019213 Purity: ≥97.0%
COA Handling Instructions

cis-4-Hydroxy-L-proline hydrochloride is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). cis-4-Hydroxy-L-proline hydrochloride is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

cis-4-Hydroxy-L-proline hydrochloride Chemical Structure

cis-4-Hydroxy-L-proline hydrochloride Chemical Structure

CAS No. : 441067-49-8

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Based on 1 publication(s) in Google Scholar

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Description

cis-4-Hydroxy-L-proline hydrochloride is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). cis-4-Hydroxy-L-proline hydrochloride is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

IC50 & Target

Non-cleavable Linker

 

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

167.59

Formula

C5H10ClNO3

CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

[H]Cl.O=C(O)[C@H]1NC[C@@H](O)C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation

Purity: ≥97.0%

References
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cis-4-Hydroxy-L-proline hydrochloride Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
cis-4-Hydroxy-L-proline hydrochloride
Cat. No.:
HY-W019213
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