1. Antibody-drug Conjugate/ADC Related
  2. ADC Linker
  3. PDEC-NB

PDEC-NB 

Cat. No.: HY-126498 Purity: 98.04%
Handling Instructions

PDEC-NB is a disulfide cleavable linker used for the antibody-drug conjugate (ADC).

For research use only. We do not sell to patients.

PDEC-NB Chemical Structure

PDEC-NB Chemical Structure

CAS No. : 874302-76-8

Size Price Stock Quantity
100 mg USD 550 In-stock
Estimated Time of Arrival: December 31
500 mg USD 1300 Get quote
1 g   Get quote  
5 g   Get quote  

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Description

PDEC-NB is a disulfide cleavable linker used for the antibody-drug conjugate (ADC)[1].

IC50 & Target[1]

Cleavable

 

Molecular Weight

352.39

Formula

C₁₄H₁₂N₂O₅S₂

CAS No.
SMILES

O=C(OCCSSC1=NC=CC=C1)OC2=CC=C([N+]([O-])=O)C=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (283.78 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8378 mL 14.1888 mL 28.3776 mL
5 mM 0.5676 mL 2.8378 mL 5.6755 mL
10 mM 0.2838 mL 1.4189 mL 2.8378 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 2.5 mg/mL (7.09 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 2.5 mg/mL (7.09 mM); Suspended solution; Need ultrasonic

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (7.09 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

PDEC-NBADC LinkerAntibody-drug conjugates linkerInhibitorinhibitorinhibit

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Product Name:
PDEC-NB
Cat. No.:
HY-126498
Quantity:
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