1. PROTAC
    Antibody-drug Conjugate/ADC Related
  2. PROTAC Linker
    ADC Linker
  3. Bis-PEG9-acid

Bis-PEG9-acid 

Cat. No.: HY-126894
Handling Instructions

Bis-​PEG9-​acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Bis-​PEG9-​acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

For research use only. We do not sell to patients.

Bis-PEG9-acid Chemical Structure

Bis-PEG9-acid Chemical Structure

CAS No. : 1268488-70-5

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Description

Bis-​PEG9-​acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Bis-​PEG9-​acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

IC50 & Target[1]

PEGs

 

Cleavable

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

514.56

Formula

C₂₂H₄₂O₁₃

CAS No.

1268488-70-5

SMILES

O=C(O)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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Keywords:

Bis-PEG9-acidPROTAC LinkerADC LinkerAntibody-drug conjugates linkerPEGPROTAClinkerE3ubiquitinligaseproteincleavableADCantibody-drugconjugatesInhibitorinhibitorinhibit

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Product Name:
Bis-PEG9-acid
Cat. No.:
HY-126894
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