2. Antibody-drug Conjugate/ADC Related
    PROTAC
  3. ADC Linker
    PROTAC Linkers
  4. Propargyl-PEG3-NHS ester

Propargyl-PEG3-NHS ester 

Cat. No.: HY-126974
Handling Instructions

Propargyl-PEG3-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG3-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

For research use only. We do not sell to patients.

Propargyl-PEG3-NHS ester Chemical Structure

Propargyl-PEG3-NHS ester Chemical Structure

CAS No. : 1428629-71-3

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Based on 1 publication(s) in Google Scholar

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PEGs Alkyl-Chain Alkyl/ether

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Description

Propargyl-PEG3-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG3-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

IC50 & Target[1]

Cleavable

 

PEGs

 

Alkyl/ether

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

313.30

Appearance

Liquid

Formula

C14H19NO7
CAS No.
SMILES

O=C(ON1C(CCC1=O)=O)CCOCCOCCOCC#C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

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Keywords:

Propargyl-PEG3-NHS ester1428629-71-3ADC LinkerPROTAC LinkersAntibody-drug conjugates linkercleavableADCantibody-drugconjugatesInhibitorinhibitorinhibit

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