2. Antibody-drug Conjugate/ADC Related PROTAC
  3. ADC Linker PROTAC Linkers
  4. Fmoc-NH-PEG2-CH2CH2COOH

Fmoc-NH-PEG2-CH2CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-NH-PEG2-CH2CH2COOH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

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Fmoc-NH-PEG2-CH2CH2COOH Chemical Structure

Fmoc-NH-PEG2-CH2CH2COOH Chemical Structure

CAS No. : 872679-70-4

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Based on 1 publication(s) in Google Scholar

Fmoc-NH-PEG2-CH2CH2COOH Related Antibodies

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Description

Fmoc-NH-PEG2-CH2CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-NH-PEG2-CH2CH2COOH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target[1]

Cleavable Linker

 

PEGs

 

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Fmoc-NH-PEG2-CH2CH2COOH Related Antibodies
Molecular Weight

399.44

Formula

C22H25NO6
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(O)CCOCCOCCNC(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (312.94 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5035 mL 12.5175 mL 25.0350 mL
5 mM 0.5007 mL 2.5035 mL 5.0070 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.79%

COA (245 KB) HNMR (267 KB) LCMS (94 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5035 mL 12.5175 mL 25.0350 mL 62.5876 mL
5 mM 0.5007 mL 2.5035 mL 5.0070 mL 12.5175 mL
10 mM 0.2504 mL 1.2518 mL 2.5035 mL 6.2588 mL
15 mM 0.1669 mL 0.8345 mL 1.6690 mL 4.1725 mL
20 mM 0.1252 mL 0.6259 mL 1.2518 mL 3.1294 mL
25 mM 0.1001 mL 0.5007 mL 1.0014 mL 2.5035 mL
30 mM 0.0835 mL 0.4173 mL 0.8345 mL 2.0863 mL
40 mM 0.0626 mL 0.3129 mL 0.6259 mL 1.5647 mL
50 mM 0.0501 mL 0.2504 mL 0.5007 mL 1.2518 mL
60 mM 0.0417 mL 0.2086 mL 0.4173 mL 1.0431 mL
80 mM 0.0313 mL 0.1565 mL 0.3129 mL 0.7823 mL
100 mM 0.0250 mL 0.1252 mL 0.2504 mL 0.6259 mL
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Fmoc-NH-PEG2-CH2CH2COOH Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fmoc-NH-PEG2-CH2CH2COOH872679-70-4ADC LinkerPROTAC LinkersAntibody-drug conjugates linkerInhibitorinhibitorinhibit

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