Mal-PEG4-Val-Cit-PAB-OH

Name: Mal-PEG4-Val-Cit-PAB-OH
Brand: MedChemExpress
SKU: HY-140143
Rating: 4.5 (1 reviews)

Cat. No.: HY-140143 Purity: 96.92%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Mal-PEG4-Val-Cit-PAB-OH is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

For research use only. We do not sell to patients.

Mal-PEG4-Val-Cit-PAB-OH Chemical Structure

CAS No. : 2055041-39-7

Size	Price	Stock	Quantity
25 mg	USD 470	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 750	In-stock	Estimated Time of Arrival: December 31
100 mg		Get quote
200 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Mal-PEG4-Val-Cit-PAB-OH is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)^[1].

IC₅₀ & Target

Protease Cleavable Linker

Cleavable Linker

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

706.78

Formula

C₃₃H₅₀N₆O₁₁

CAS No.

2055041-39-7

Appearance

Solid

Color

White to off-white

SMILES

OCC(C=C1)=CC=C1NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCOCCOCCOCCOCCN2C(C=CC2=O)=O)=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (176.86 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.4149 mL	7.0743 mL	14.1487 mL
5 mM	0.2830 mL	1.4149 mL	2.8297 mL
10 mM	0.1415 mL	0.7074 mL	1.4149 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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Dosing volume
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μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 96.92%

Select Batch:

Data Sheet (268 KB) SDS (393 KB)

COA (244 KB) HNMR (329 KB) RP-HPLC (229 KB) LCMS (93 KB)

Handling Instructions (2659 KB)

References

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.4149 mL	7.0743 mL	14.1487 mL	35.3717 mL
	5 mM	0.2830 mL	1.4149 mL	2.8297 mL	7.0743 mL
	10 mM	0.1415 mL	0.7074 mL	1.4149 mL	3.5372 mL
	15 mM	0.0943 mL	0.4716 mL	0.9432 mL	2.3581 mL
	20 mM	0.0707 mL	0.3537 mL	0.7074 mL	1.7686 mL
	25 mM	0.0566 mL	0.2830 mL	0.5659 mL	1.4149 mL
	30 mM	0.0472 mL	0.2358 mL	0.4716 mL	1.1791 mL
	40 mM	0.0354 mL	0.1769 mL	0.3537 mL	0.8843 mL
	50 mM	0.0283 mL	0.1415 mL	0.2830 mL	0.7074 mL
	60 mM	0.0236 mL	0.1179 mL	0.2358 mL	0.5895 mL
	80 mM	0.0177 mL	0.0884 mL	0.1769 mL	0.4421 mL
	100 mM	0.0141 mL	0.0707 mL	0.1415 mL	0.3537 mL