Azido-PEG3-Val-Cit-PAB-PNP
Based on 1 Customer Validation
Azido-PEG3-Val-Cit-PAB-PNP is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azido-PEG3-Val-Cit-PAB-PNP is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG3-Val-Cit-PAB-PNP is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
For research use only. We do not sell to patients.
- Purity: 99.21%
- CAS No.: 2055047-18-0
- Formula: C34H47N9O12
- Molecular Weight:773.79
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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HY-20336
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HY-140149
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HY-15575
VcMMAE
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HY-12362
Val-cit-PAB-OH
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HY-41189
Fmoc-Val-Cit-PAB-PNP
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HY-78738
MC-Val-Cit-PAB
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HY-19318
Fmoc-Val-Cit-PAB
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HY-141142
Boc-Val-Cit-PAB-PNP
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HY-140145
Mal-PEG4-Val-Cit-PAB-PNP
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HY-141141
Boc-Val-Cit-PAB
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HY-W038702
Boc-Val-Cit-OH
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HY-130944
Mal-PEG1-Val-Cit-PABC-OH
All PROTAC Linkers Isoforms
More
Biological Activity
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PEGs |
Protease Cleavable Linker |
Cleavable Linker |
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2055047-18-0
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Appearance Solid
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Molecular Weight 773.79
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Formula C34H47N9O12
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Color White to light yellow
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SMILES
O=C(NC(C=C1)=CC=C1COC(OC(C=C2)=CC=C2[N](=O)=O)=O)[C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCOCCOCCOCCN=[N+]=[N-])=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 116.67 mg/mL (150.78 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
[1]. Dan N, et al. Antibody-Drug Conjugates for Cancer Therapy: Chemistry to Clinical Implications. Pharmaceuticals (Basel). 2018 Apr 9;11(2). pii: E32. [Content Brief]
[2]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.2923 mL | 6.4617 mL | 12.9234 mL | 32.3085 mL |
| 5 mM | 0.2585 mL | 1.2923 mL | 2.5847 mL | 6.4617 mL | |
| 10 mM | 0.1292 mL | 0.6462 mL | 1.2923 mL | 3.2309 mL | |
| 15 mM | 0.0862 mL | 0.4308 mL | 0.8616 mL | 2.1539 mL | |
| 20 mM | 0.0646 mL | 0.3231 mL | 0.6462 mL | 1.6154 mL | |
| 25 mM | 0.0517 mL | 0.2585 mL | 0.5169 mL | 1.2923 mL | |
| 30 mM | 0.0431 mL | 0.2154 mL | 0.4308 mL | 1.0770 mL | |
| 40 mM | 0.0323 mL | 0.1615 mL | 0.3231 mL | 0.8077 mL | |
| 50 mM | 0.0258 mL | 0.1292 mL | 0.2585 mL | 0.6462 mL | |
| 60 mM | 0.0215 mL | 0.1077 mL | 0.2154 mL | 0.5385 mL | |
| 80 mM | 0.0162 mL | 0.0808 mL | 0.1615 mL | 0.4039 mL | |
| 100 mM | 0.0129 mL | 0.0646 mL | 0.1292 mL | 0.3231 mL |
Azido-PEG3-Val-Cit-PAB-PNP Related Classifications
HY-140150 Related Classifications
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