Azido-PEG3-Val-Cit-PAB-PNP

Name: Azido-PEG3-Val-Cit-PAB-PNP
Brand: MedChemExpress
SKU: HY-140150
Rating: 4.5 (1 reviews)

製品番号: HY-140150 純度: 99.21%: Data Sheet SDS COA 取扱説明書
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Technical Support

Azido-PEG3-Val-Cit-PAB-PNP is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azido-PEG3-Val-Cit-PAB-PNP is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG3-Val-Cit-PAB-PNP is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

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Azido-PEG3-Val-Cit-PAB-PNP 構造式

CAS 番号 : 2055047-18-0

容量	価格（税別）	在庫状況	数量
>無料サンプル (0.1 - 0.2 mg)		今すぐ申し込む
5 mg	$140	在庫あり	Estimated Time of Arrival: December 31
10 mg	$220	在庫あり	Estimated Time of Arrival: December 31
25 mg	$440	在庫あり	Estimated Time of Arrival: December 31
50 mg	$700	在庫あり	Estimated Time of Arrival: December 31
100 mg	$1120	在庫あり	Estimated Time of Arrival: December 31
200 mg		お問い合わせ
500 mg		お問い合わせ

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* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 1 publication(s) in Google Scholar

ADC Linker アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

Cleavable Linker Non-cleavable Linker Acid Cleavable Linker Disulfide Cleavable Linker Protease Cleavable Linker Glycosidase Cleavable Linker Phosphatase Cleavable Linker

PROTAC Linkers アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

PEG Linkers Alkyl-Chain Linkers Alkyl/ether Linkers

生物活性
純度とドキュメンテーション
参考文献
カスタマーレビュー

製品説明

Azido-PEG3-Val-Cit-PAB-PNP is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)^[1]. Azido-PEG3-Val-Cit-PAB-PNP is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs^[2]. Azido-PEG3-Val-Cit-PAB-PNP is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

IC₅₀ & Target^[1]^[2]

PEGs

Protease Cleavable Linker

Cleavable Linker

体外実験

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker^[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

773.79

分子式

C₃₄H₄₇N₉O₁₂

CAS 番号

2055047-18-0

Appearance

Solid

Color

White to light yellow

SMILES

O=C(NC(C=C1)=CC=C1COC(OC(C=C2)=CC=C2[N](=O)=O)=O)[C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCOCCOCCOCCN=[N+]=[N-])=O)=O

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶剤 & 溶解度

体外:

DMSO : 116.67 mg/mL (150.78 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.2923 mL	6.4617 mL	12.9234 mL
5 mM	0.2585 mL	1.2923 mL	2.5847 mL
10 mM	0.1292 mL	0.6462 mL	1.2923 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

純度とドキュメンテーション

純度: 99.21%

Select Batch:

データシート (271 KB) SDS (394 KB)

COA (246 KB) HNMR (341 KB) RP-HPLC (267 KB) MS (68 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Dan N, et al. Antibody-Drug Conjugates for Cancer Therapy: Chemistry to Clinical Implications. Pharmaceuticals (Basel). 2018 Apr 9;11(2). pii: E32. [Content Brief]

[2]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.2923 mL	6.4617 mL	12.9234 mL	32.3085 mL
	5 mM	0.2585 mL	1.2923 mL	2.5847 mL	6.4617 mL
	10 mM	0.1292 mL	0.6462 mL	1.2923 mL	3.2309 mL
	15 mM	0.0862 mL	0.4308 mL	0.8616 mL	2.1539 mL
	20 mM	0.0646 mL	0.3231 mL	0.6462 mL	1.6154 mL
	25 mM	0.0517 mL	0.2585 mL	0.5169 mL	1.2923 mL
	30 mM	0.0431 mL	0.2154 mL	0.4308 mL	1.0770 mL
	40 mM	0.0323 mL	0.1615 mL	0.3231 mL	0.8077 mL
	50 mM	0.0258 mL	0.1292 mL	0.2585 mL	0.6462 mL
	60 mM	0.0215 mL	0.1077 mL	0.2154 mL	0.5385 mL
	80 mM	0.0162 mL	0.0808 mL	0.1615 mL	0.4039 mL
	100 mM	0.0129 mL	0.0646 mL	0.1292 mL	0.3231 mL