1. Antibody-drug Conjugate/ADC Related
    PROTAC
  2. ADC Linker
    PROTAC Linker
  3. Boc-NH-PEG1-CH2CH2COOH

Boc-NH-PEG1-CH2CH2COOH 

Cat. No.: HY-120775
Handling Instructions

Boc-NH-PEG1-CH2CH2COOH is a cleavable (1 unit PEG) ADC linker and also a PEG- and Alkyl/ether-based PROTAC linker can be used in the synthesis of antibody-drug conjugates (ADCs) or PROTACs.

For research use only. We do not sell to patients.

Boc-NH-PEG1-CH2CH2COOH Chemical Structure

Boc-NH-PEG1-CH2CH2COOH Chemical Structure

CAS No. : 1260092-44-1

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Description

Boc-NH-PEG1-CH2CH2COOH is a cleavable (1 unit PEG) ADC linker and also a PEG- and Alkyl/ether-based PROTAC linker can be used in the synthesis of antibody-drug conjugates (ADCs) or PROTACs[1][2].

IC50 & Target[1]

PEGs

 

Alkyl/ether

 

Cleavable

 

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].

Molecular Weight

233.26

Formula

C₁₀H₁₉NO₅

CAS No.

1260092-44-1

SMILES

CC(C)(OC(NCCOCCC(O)=O)=O)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Boc-NH-PEG1-CH2CH2COOHADC LinkerPROTAC LinkerAntibody-drug conjugates linkerPROTACPEG-basedlinkerAlkyletherInhibitorinhibitorinhibit

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Boc-NH-PEG1-CH2CH2COOH
Cat. No.:
HY-120775
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