DBCO-NHCO-PEG4-amine TFA
Based on 1 Customer Validation
DBCO-NHCO-PEG4-amine TFA is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. DBCO-NHCO-PEG4-amine TFA is a cleavable ADC linker used to conjugate MMAE (HY-15162) and antibody (e.g., DBCO-VCpAB MMAE and DBCO-TRX MMAE with EC50s of 280 nM and 22 nM in SKBR3 cells, respectively).
For research use only. We do not sell to patients.
- Purity: 96.74%
- Formula: C31H38F3N3O8
- Molecular Weight:637.64
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Storage:Pure form -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All PROTAC Linkers Isoforms
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Biological Activity
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PEGs |
Cleavable Linker |
Chemical Information
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Appearance Oil
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Molecular Weight 637.64
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Formula C31H38F3N3O8
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Color Light yellow to brown
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SMILES
O=C(N1CC2=C(C#CC3=C1C=CC=C3)C=CC=C2)CCNC(CCOCCOCCOCCOCCN)=O.O=C(O)C(F)(F)F
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Pure form -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
H2O : 50 mg/mL (78.41 mM; ultrasonic and warming and heat to 60°C)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (268 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| H2O | 1 mM | 1.5683 mL | 7.8414 mL | 15.6828 mL | 39.2071 mL |
| 5 mM | 0.3137 mL | 1.5683 mL | 3.1366 mL | 7.8414 mL | |
| 10 mM | 0.1568 mL | 0.7841 mL | 1.5683 mL | 3.9207 mL | |
| 15 mM | 0.1046 mL | 0.5228 mL | 1.0455 mL | 2.6138 mL | |
| 20 mM | 0.0784 mL | 0.3921 mL | 0.7841 mL | 1.9604 mL | |
| 25 mM | 0.0627 mL | 0.3137 mL | 0.6273 mL | 1.5683 mL | |
| 30 mM | 0.0523 mL | 0.2614 mL | 0.5228 mL | 1.3069 mL | |
| 40 mM | 0.0392 mL | 0.1960 mL | 0.3921 mL | 0.9802 mL | |
| 50 mM | 0.0314 mL | 0.1568 mL | 0.3137 mL | 0.7841 mL | |
| 60 mM | 0.0261 mL | 0.1307 mL | 0.2614 mL | 0.6535 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
DBCO-NHCO-PEG4-amine TFA Related Classifications
HY-124386A Related Classifications
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