DBCO-NHCO-PEG4-amine TFA

Name: DBCO-NHCO-PEG4-amine TFA
Brand: MedChemExpress
SKU: HY-124386A
Rating: 4.5 (0 reviews)

Cat. No.: HY-124386A Purity: 96.74%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

DBCO-NHCO-PEG4-amine TFA is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. DBCO-NHCO-PEG4-amine TFA is a cleavable ADC linker used to conjugate MMAE (HY-15162) and antibody (e.g., DBCO-VCpAB MMAE and DBCO-TRX MMAE with EC₅₀s of 280 nM and 22 nM in SKBR3 cells, respectively).

For research use only. We do not sell to patients.

DBCO-NHCO-PEG4-amine TFA Chemical Structure

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Other Forms of DBCO-NHCO-PEG4-amine TFA:

DBCO-NHCO-PEG4-amine In-stock

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•Related Small Molecules:

•Related Proteins:

View All ADC Linker Isoform Specific Products:

View All Isoforms

Cleavable Linker Non-cleavable Linker Acid Cleavable Linker Disulfide Cleavable Linker Protease Cleavable Linker Glycosidase Cleavable Linker Phosphatase Cleavable Linker

View All PROTAC Linkers Isoform Specific Products:

View All Isoforms

PEG Linkers Alkyl-Chain Linkers Alkyl/ether Linkers

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target^[1]

PEGs	Cleavable Linker

Molecular Weight

637.64

Formula

C₃₁H₃₈F₃N₃O₈

Appearance

Oil

Color

Light yellow to brown

SMILES

O=C(N1CC2=C(C#CC3=C1C=CC=C3)C=CC=C2)CCNC(CCOCCOCCOCCOCCN)=O.O=C(O)C(F)(F)F

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Pure form	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

H₂O : 50 mg/mL (78.41 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.5683 mL	7.8414 mL	15.6828 mL
5 mM	0.3137 mL	1.5683 mL	3.1366 mL
10 mM	0.1568 mL	0.7841 mL	1.5683 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 96.74%

Select Batch:

Data Sheet (268 KB) SDS (251 KB)

COA (244 KB) HNMR (318 KB) CNMR (294 KB) LCMS (110 KB)

Handling Instructions (2659 KB)

References

[1]. Spangler B, et al. Toward a Ferrous Iron-Cleavable Linker for Antibody-Drug Conjugates. Mol Pharm. 2018 May 7;15(5):2054-2059. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	1.5683 mL	7.8414 mL	15.6828 mL	39.2071 mL
	5 mM	0.3137 mL	1.5683 mL	3.1366 mL	7.8414 mL
	10 mM	0.1568 mL	0.7841 mL	1.5683 mL	3.9207 mL
	15 mM	0.1046 mL	0.5228 mL	1.0455 mL	2.6138 mL
	20 mM	0.0784 mL	0.3921 mL	0.7841 mL	1.9604 mL
	25 mM	0.0627 mL	0.3137 mL	0.6273 mL	1.5683 mL
	30 mM	0.0523 mL	0.2614 mL	0.5228 mL	1.3069 mL
	40 mM	0.0392 mL	0.1960 mL	0.3921 mL	0.9802 mL
	50 mM	0.0314 mL	0.1568 mL	0.3137 mL	0.7841 mL
	60 mM	0.0261 mL	0.1307 mL	0.2614 mL	0.6535 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.