2. PROTAC Antibody-drug Conjugate/ADC Related
  3. PROTAC Linkers ADC Linker
  4. m-PEG12-amine

m-PEG12-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. m-PEG12-amine is also a non-cleavable 12 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

For research use only. We do not sell to patients.

m-PEG12-amine Chemical Structure

m-PEG12-amine Chemical Structure

CAS No. : 1977493-48-3

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Based on 1 publication(s) in Google Scholar

m-PEG12-amine Related Antibodies

Top Publications Citing Use of Products

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  • Biological Activity

  • Purity & Documentation

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  • Customer Review

Description

m-PEG12-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. m-PEG12-amine is also a non-cleavable 12 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2].

IC50 & Target[1][2]

PEGs

 

Non-cleavable Linker

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

m-PEG12-amine Related Antibodies
Molecular Weight

559.69

Formula

C25H53NO12
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

COCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (178.67 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7867 mL 8.9335 mL 17.8670 mL
5 mM 0.3573 mL 1.7867 mL 3.5734 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥98.0%

COA (238 KB) HNMR (255 KB) MS (69 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7867 mL 8.9335 mL 17.8670 mL 44.6676 mL
5 mM 0.3573 mL 1.7867 mL 3.5734 mL 8.9335 mL
10 mM 0.1787 mL 0.8934 mL 1.7867 mL 4.4668 mL
15 mM 0.1191 mL 0.5956 mL 1.1911 mL 2.9778 mL
20 mM 0.0893 mL 0.4467 mL 0.8934 mL 2.2334 mL
25 mM 0.0715 mL 0.3573 mL 0.7147 mL 1.7867 mL
30 mM 0.0596 mL 0.2978 mL 0.5956 mL 1.4889 mL
40 mM 0.0447 mL 0.2233 mL 0.4467 mL 1.1167 mL
50 mM 0.0357 mL 0.1787 mL 0.3573 mL 0.8934 mL
60 mM 0.0298 mL 0.1489 mL 0.2978 mL 0.7445 mL
80 mM 0.0223 mL 0.1117 mL 0.2233 mL 0.5583 mL
100 mM 0.0179 mL 0.0893 mL 0.1787 mL 0.4467 mL
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m-PEG12-amine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

m-PEG12-amine1977493-48-3PROTAC LinkersADC LinkerAntibody-drug conjugates linkerPEGADClinkerPROTACnon-cleavableInhibitorinhibitorinhibit

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