country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-174984

Copy Link Print Information

VCP/p97 IN-3

VCP/p97 IN-3 is a VCP/p97 allosteric inhibitor. VCP/p97 IN-3 shows the inhibitory activity against the VCP proteins with an IC₅₀ of 9 nM and the mutant VCP proteins with IC₅₀ of 12 nM (N660K) and 19 nM (V474A/D649A). VCP/p97 IN-3 increases K48-linked ubiquitination and the level of cleaved caspase-3. VCP/p97 IN-3 activates ER-stress and the UPR. VCP/p97 IN-3 inhibits tumor growth in RPMI-8226 cell subcutaneous xenograft mouse models. VCP/p97 IN-3 can be used for the study of multiple myeloma.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

CAS No.: 3098437-66-9
Formule: C₃₁H₃₂F₂N₆O₃S
Masse moléculaire:606.69

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

VCP/p97 IN-3 Chemical Structure

CAS No.: 3098437-66-9

Size

Prix

Stock

Quantité

Amount: USD 0.00

* Veuillez sélectionner la quantité avant d'ajouter des articles.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Parmacokinetics
- In Vivo
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Voir tous les produits spécifiques à Isoform Caspase :

Parmacokinetics

Species	Dose	Route	CL	V_ss	C_max	AUC_last
Mice^[1]	5 mg/kg	i.v.	4.0 L/h/kg	608 L/kg	/	/
Mice^[1]	50 mg/kg	i.p.	/	/	17.4 μM	42.0 μM·h
Mice^[1]	50 mg/kg	p.o.	/	/	0.7 μM	2.0 μM·h

In Vivo

VCP/p97 IN-3 (Compound 38) (50-100 mg/kg, i.p., every other day, 23 days) inhibits tumor growth in RPMI-8226 cell subcutaneous xenograft mouse models^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

RPMI-8226 cell subcutaneous xenograft mice^[1]
Dosage:

50, 100 mg/kg
Administration:

i.p. every other day, 23 days
Result:

Increased the ubiquitin of K48 and the level of cleaved caspase-3.
Activated endoplasmic reticulum (ER)-stress and the UPR, as assessed by increases in phosphorylated-eIF2α (p-eIF2α), activation transcription factor 4 (ATF4),74 and glucose-regulated protein (BiP/GRP78).
Activated the DNA damage response as observed from the 2.5-fold increase in phosphorylated Histone 2A (H2A.X).
Reduced p62 levels.
Showed a TGI of 73% on day 23.
Suffered a mean 10% loss in body weight.

Chemical Information

CAS No. 3098437-66-9
Masse moléculaire 606.69
Formule C₃₁H₃₂F₂N₆O₃S
SMILES

O=C(OCC#CC1=CC(F)=C(OCC2=NN=C(S[C@H]3C=CCCC3)N2C4=CC=CN=C4)C=C1F)NC(C5)CC65CN(C)C6
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Green N, et al. Antitumor Efficacy of 1,2,4-Triazole-Based VCP/p97 Allosteric Inhibitors. J Med Chem. 2025 Jul 24;68(14):14465-14494. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

Obtenir un devis En stock

Other size

Obtenir un devis

Amount: USD 0.00

Activité biologique
- Description
- In Vivo
Chemical Information
Pureté et documentation
Références

Nom du produit:
Cat. No.:
Quantité:
MCE Japan Authorized Agent:

Nom du produit:
CAS No.:
Species:
Pureté:
Quantité:

VCP/p97 IN-3

Voir tous les produits spécifiques à Isoform Caspase

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

VCP/p97 IN-3 Related Classifications

HY-174984 Related Classifications