2. Antibody-drug Conjugate/ADC Related
  3. ADC Linker
  4. MDTF free acid

MDTF free acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

At equivalent molar concentrations, both the salt and free forms of a compound exhibit comparable biological activity. Nevertheless, the salt form (MDTF) usually boasts enhanced water solubility and stability.

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MDTF free acid Chemical Structure

MDTF free acid Chemical Structure

CAS No. : 2102021-49-6

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Other In-stock Forms of MDTF free acid:

Other Forms of MDTF free acid:

MDTF free acid Related Antibodies

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Description

MDTF free acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

In Vitro

MDTF free acid (50 μM) increases hydrophilic character by substitution of a cyclohexyl ring and a MD-based FRET probe incubates in human plasma has a considerably higher self-stabilization rate compared to the MCC-based probe[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MDTF free acid Related Antibodies
Molecular Weight

469.32

Formula

C16H11F4NO9S
CAS No.
SMILES

O=C([C@H]1CO[C@H](OC1)CN2C(C=CC2=O)=O)OC3=C(C(F)=C(C(F)=C3F)S(=O)(O)=O)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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MDTF free acid Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MDTF2102021-49-6ADC LinkerAntibody-drug conjugates linkerSMCCADC linkerhydrophiliccyclohexyl ringself-stabilizationInhibitorinhibitorinhibit

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