Mal-PEG8-Val-Ala-PABC
Mal-PEG8-Val-Ala-PABC (MP-PEG8-Val-Ala-PABC; MP-PEG8-VA-PABC) is a type of cleavable ADC linker that can be used for the synthesis of ADCs.
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- Purity: 99.18%
- 화학식: C41H65N5O15
- 분자량:867.98
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보관:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
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Help & FAQs
Biological Activity
Mal-PEG8-Val-Ala-PABC consists of a maleimide (Mal) for thiol-reactive conjugation, a hydrophilic PEG8 spacer, a cathepsin-cleavable Val-Ala dipeptide, and a p-aminobenzyl carbamate (PABC/PAB) self-immolative spacer.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Appearance Viscous Liquid
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분자량 867.98
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화학식 C41H65N5O15
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Color Colorless to light pink
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SMILES
O=C([C@@H](NC([C@@H](NC(CCOCCOCCOCCOCCOCCOCCOCCOCCNC(CCN1C(C=CC1=O)=O)=O)=O)C(C)C)=O)C)NC2=CC=C(C=C2)CO
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Synonyms
MP-PEG8-Val-Ala-PABC; MP-PEG8-VA-PABC
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선적
Room temperature in continental US; may vary elsewhere.
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보관
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
용액&용해도
DMSO : 100 mg/mL (115.21 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : < 0.1 mg/mL (insoluble)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (244 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.1521 mL | 5.7605 mL | 11.5210 mL | 28.8025 mL |
| 5 mM | 0.2304 mL | 1.1521 mL | 2.3042 mL | 5.7605 mL | |
| 10 mM | 0.1152 mL | 0.5761 mL | 1.1521 mL | 2.8803 mL | |
| 15 mM | 0.0768 mL | 0.3840 mL | 0.7681 mL | 1.9202 mL | |
| 20 mM | 0.0576 mL | 0.2880 mL | 0.5761 mL | 1.4401 mL | |
| 25 mM | 0.0461 mL | 0.2304 mL | 0.4608 mL | 1.1521 mL | |
| 30 mM | 0.0384 mL | 0.1920 mL | 0.3840 mL | 0.9601 mL | |
| 40 mM | 0.0288 mL | 0.1440 mL | 0.2880 mL | 0.7201 mL | |
| 50 mM | 0.0230 mL | 0.1152 mL | 0.2304 mL | 0.5761 mL | |
| 60 mM | 0.0192 mL | 0.0960 mL | 0.1920 mL | 0.4800 mL | |
| 80 mM | 0.0144 mL | 0.0720 mL | 0.1440 mL | 0.3600 mL | |
| 100 mM | 0.0115 mL | 0.0576 mL | 0.1152 mL | 0.2880 mL |
Mal-PEG8-Val-Ala-PABC Related Classifications
HY-132252 Related Classifications
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