1. Antibody-drug Conjugate/ADC Related
  2. ADC Linker
  3. Mal-PEG8-Val-Ala-PABC

Mal-PEG8-Val-Ala-PABC is a cleavable Tesirine linker used in the synthesis of Tesirine, a agent-linker conjugate for ADC.

For research use only. We do not sell to patients.

Mal-PEG8-Val-Ala-PABC Chemical Structure

Mal-PEG8-Val-Ala-PABC Chemical Structure

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50 mg USD 650 In-stock
100 mg USD 1100 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Mal-PEG8-Val-Ala-PABC is a cleavable Tesirine linker used in the synthesis of Tesirine, a agent-linker conjugate for ADC[1].

Molecular Weight

867.98

Formula

C41H65N5O15

Appearance

Viscous Liquid

Color

Colorless to light pink

SMILES

O=C([C@@H](NC([C@@H](NC(CCOCCOCCOCCOCCOCCOCCOCCOCCNC(CCN1C(C=CC1=O)=O)=O)=O)C(C)C)=O)C)NC2=CC=C(C=C2)CO

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (115.21 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.1521 mL 5.7605 mL 11.5210 mL
5 mM 0.2304 mL 1.1521 mL 2.3042 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.1521 mL 5.7605 mL 11.5210 mL 28.8025 mL
5 mM 0.2304 mL 1.1521 mL 2.3042 mL 5.7605 mL
10 mM 0.1152 mL 0.5761 mL 1.1521 mL 2.8803 mL
15 mM 0.0768 mL 0.3840 mL 0.7681 mL 1.9202 mL
20 mM 0.0576 mL 0.2880 mL 0.5761 mL 1.4401 mL
25 mM 0.0461 mL 0.2304 mL 0.4608 mL 1.1521 mL
30 mM 0.0384 mL 0.1920 mL 0.3840 mL 0.9601 mL
40 mM 0.0288 mL 0.1440 mL 0.2880 mL 0.7201 mL
50 mM 0.0230 mL 0.1152 mL 0.2304 mL 0.5761 mL
60 mM 0.0192 mL 0.0960 mL 0.1920 mL 0.4800 mL
80 mM 0.0144 mL 0.0720 mL 0.1440 mL 0.3600 mL
100 mM 0.0115 mL 0.0576 mL 0.1152 mL 0.2880 mL
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Mal-PEG8-Val-Ala-PABC Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Mal-PEG8-Val-Ala-PABC
Cat. No.:
HY-132252
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