BCN-SS-NHS
Based on 1 Customer Validation
BCN-SS-NHS is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). BCN-SS-NHS is a click chemistry reagent, it contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
For research use only. We do not sell to patients.
- Purity: 95.0%
- CAS No.: 2751350-71-5
- Formula: C20H26N2O6S2
- Molecular Weight:454.56
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Disulfide Cleavable Linker |
Cleavable Linker |
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2751350-71-5
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Appearance Oil
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Molecular Weight 454.56
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Formula C20H26N2O6S2
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Color Colorless to light yellow
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SMILES
O=C(NCCSSCCC(ON1C(CCC1=O)=O)=O)OC[C@H]2[C@@]3([H])CCC#CCC[C@@]23[H]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 100 mg/mL (219.99 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (269 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.1999 mL | 10.9996 mL | 21.9993 mL | 54.9982 mL |
| 5 mM | 0.4400 mL | 2.1999 mL | 4.3999 mL | 10.9996 mL | |
| 10 mM | 0.2200 mL | 1.1000 mL | 2.1999 mL | 5.4998 mL | |
| 15 mM | 0.1467 mL | 0.7333 mL | 1.4666 mL | 3.6665 mL | |
| 20 mM | 0.1100 mL | 0.5500 mL | 1.1000 mL | 2.7499 mL | |
| 25 mM | 0.0880 mL | 0.4400 mL | 0.8800 mL | 2.1999 mL | |
| 30 mM | 0.0733 mL | 0.3667 mL | 0.7333 mL | 1.8333 mL | |
| 40 mM | 0.0550 mL | 0.2750 mL | 0.5500 mL | 1.3750 mL | |
| 50 mM | 0.0440 mL | 0.2200 mL | 0.4400 mL | 1.1000 mL | |
| 60 mM | 0.0367 mL | 0.1833 mL | 0.3667 mL | 0.9166 mL | |
| 80 mM | 0.0275 mL | 0.1375 mL | 0.2750 mL | 0.6875 mL | |
| 100 mM | 0.0220 mL | 0.1100 mL | 0.2200 mL | 0.5500 mL |
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