OH-Glu-Val-Cit-PAB-MMAE

Cat. No.: HY-148245 Purity: 99.92%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

OH-Glu-Val-Cit-PAB-MMAE consists a cleavable ADC linker (OH-Glu-Val-Cit-PAB) and a potent tubulin inhibitor (MMAE). SuO-Glu-Val-Cit-PAB-MMAE can be used in the synthesis of antibody-drug conjugates (ADCs).

For research use only. We do not sell to patients.

OH-Glu-Val-Cit-PAB-MMAE Chemical Structure

CAS No. : 1895916-23-0

Size	Price	Stock	Quantity
5 mg	USD 620	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 980	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 1950	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 3250	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 5200	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Molecular Weight

1237.53

Formula

C₆₃H₁₀₀N₁₀O₁₅

CAS No.

1895916-23-0

Appearance

Solid

Color

White to off-white

SMILES

O[C@@H](C1=CC=CC=C1)[C@@H](C)NC([C@H](C)[C@H]([C@@]2([H])N(CCC2)C(C[C@@H](OC)[C@H]([C@@H](C)CC)N(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)C(OCC3=CC=C(C=C3)NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCCC(O)=O)=O)=O)=O)=O)=O)=O)=O)OC)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

DMSO : 180 mg/mL (145.45 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.8081 mL	4.0403 mL	8.0806 mL
5 mM	0.1616 mL	0.8081 mL	1.6161 mL
10 mM	0.0808 mL	0.4040 mL	0.8081 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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Dosing volume
(per animal)

μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.92%

Select Batch:

Data Sheet (269 KB) SDS (252 KB)

COA (250 KB) HNMR (177 KB) LCMS (96 KB)

Handling Instructions (2659 KB)

References

[1]. Gemma E Mudd, et al. Discovery of BT8009: A Nectin-4 Targeting Bicycle Toxin Conjugate for the Treatment of Cancer. J Med Chem. 2022 Nov 10;65(21):14337-14347. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	0.8081 mL	4.0403 mL	8.0806 mL	20.2015 mL
	5 mM	0.1616 mL	0.8081 mL	1.6161 mL	4.0403 mL
	10 mM	0.0808 mL	0.4040 mL	0.8081 mL	2.0202 mL
	15 mM	0.0539 mL	0.2694 mL	0.5387 mL	1.3468 mL
	20 mM	0.0404 mL	0.2020 mL	0.4040 mL	1.0101 mL
	25 mM	0.0323 mL	0.1616 mL	0.3232 mL	0.8081 mL
	30 mM	0.0269 mL	0.1347 mL	0.2694 mL	0.6734 mL
	40 mM	0.0202 mL	0.1010 mL	0.2020 mL	0.5050 mL
	50 mM	0.0162 mL	0.0808 mL	0.1616 mL	0.4040 mL
	60 mM	0.0135 mL	0.0673 mL	0.1347 mL	0.3367 mL
	80 mM	0.0101 mL	0.0505 mL	0.1010 mL	0.2525 mL
	100 mM	0.0081 mL	0.0404 mL	0.0808 mL	0.2020 mL