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Cat. No.: HY-148245S

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OH-Glu-Val-Cit-PAB-MMAE-d₈

OH-Glu-Val-Cit-PAB-MMAE-d₈ is the deuterated-labeled OH-Glu-Val-Cit-PAB-MMAE (HY-148245). OH-Glu-Val-Cit-PAB-MMAE consists a cleavable ADC linker (OH-Glu-Val-Cit-PAB) and a potent tubulin inhibitor (MMAE). SuO-Glu-Val-Cit-PAB-MMAE can be used in the synthesis of antibody-drug conjugates (ADCs).

For research use only. We do not sell to patients.

Formula: C₆₃H₉₂D₈N₁₀O₁₅
Molecular Weight:1245.58

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

OH-Glu-Val-Cit-PAB-MMAE-d₈ Chemical Structure

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Biological Activity
- Description
- In Vitro
- Application
Chemical Information
Purity & Documentation
References
Calculators
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Bioz

Biological Activity

Description

All Drug-Linker Conjugates for ADC Isoforms :

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Application

1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

Chemical Information

Unlabeled CAS 1895916-23-0
Molecular Weight 1245.58
Formula C₆₃H₉₂D₈N₁₀O₁₅
SMILES

O=C(N([C@@H]([C@@H](C)CC)[C@H](OC)CC(N1[C@H]([C@H](OC)[C@@H](C)C(N[C@H](C)[C@@H](O)C2=CC=CC=C2)=O)CCC1)=O)C)[C@@]([2H])(NC([C@@H](N(C(OCC3=CC=C(C=C3)NC([C@@H](NC([C@@H](NC(CCCC(O)=O)=O)C(C)C)=O)CCCNC(N)=O)=O)=O)C)C(C)C)=O)C([2H])(C([2H])([2H])[2H])C([2H])([2H])[2H]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Gemma E Mudd, et al. Discovery of BT8009: A Nectin-4 Targeting Bicycle Toxin Conjugate for the Treatment of Cancer. J Med Chem. 2022 Nov 10;65(21):14337-14347. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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Biological Activity
- Description
- In Vitro
- Application
Chemical Information
Purity & Documentation
References

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OH-Glu-Val-Cit-PAB-MMAE-d8

All Drug-Linker Conjugates for ADC Isoforms