1. PROTAC
  2. PROTAC Linkers
  3. Hydroxy-PEG6-acid

Hydroxy-PEG6-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

Hydroxy-PEG6-acid Chemical Structure

Hydroxy-PEG6-acid Chemical Structure

CAS No. : 1347750-85-9

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50 mg USD 70 In-stock
100 mg USD 110 In-stock
250 mg USD 180 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Hydroxy-PEG6-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

354.39

Formula

C15H30O9

CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

O=C(O)CCOCCOCCOCCOCCOCCOCCO

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (282.18 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8217 mL 14.1087 mL 28.2175 mL
5 mM 0.5643 mL 2.8217 mL 5.6435 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8217 mL 14.1087 mL 28.2175 mL 70.5437 mL
5 mM 0.5643 mL 2.8217 mL 5.6435 mL 14.1087 mL
10 mM 0.2822 mL 1.4109 mL 2.8217 mL 7.0544 mL
15 mM 0.1881 mL 0.9406 mL 1.8812 mL 4.7029 mL
20 mM 0.1411 mL 0.7054 mL 1.4109 mL 3.5272 mL
25 mM 0.1129 mL 0.5643 mL 1.1287 mL 2.8217 mL
30 mM 0.0941 mL 0.4703 mL 0.9406 mL 2.3515 mL
40 mM 0.0705 mL 0.3527 mL 0.7054 mL 1.7636 mL
50 mM 0.0564 mL 0.2822 mL 0.5643 mL 1.4109 mL
60 mM 0.0470 mL 0.2351 mL 0.4703 mL 1.1757 mL
80 mM 0.0353 mL 0.1764 mL 0.3527 mL 0.8818 mL
100 mM 0.0282 mL 0.1411 mL 0.2822 mL 0.7054 mL
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Hydroxy-PEG6-acid Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Hydroxy-PEG6-acid
Cat. No.:
HY-133050
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