Bis-PEG13-NHS ester
Based on 1 Customer Validation
Bis-PEG13-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. Bis-PEG13-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
For research use only. We do not sell to patients.
- Purity: 98.0%
- CAS No.: 2221949-00-2
- Formula: C38H64N2O21
- Molecular Weight:884.92
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All PROTAC Linkers Isoforms
More
Biological Activity
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PEGs |
Alkyl/ether |
Cleavable Linker |
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2221949-00-2
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Appearance Solid-Liquid Mixture
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Molecular Weight 884.92
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Formula C38H64N2O21
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Color Colorless to off-white
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SMILES
O=C(ON1C(CCC1=O)=O)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(ON2C(CCC2=O)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 100 mg/mL (113.00 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Ethanol : 50 mg/mL (56.50 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| Ethanol / DMSO | 1 mM | 1.1300 mL | 5.6502 mL | 11.3005 mL | 28.2511 mL |
| 5 mM | 0.2260 mL | 1.1300 mL | 2.2601 mL | 5.6502 mL | |
| 10 mM | 0.1130 mL | 0.5650 mL | 1.1300 mL | 2.8251 mL | |
| 15 mM | 0.0753 mL | 0.3767 mL | 0.7534 mL | 1.8834 mL | |
| 20 mM | 0.0565 mL | 0.2825 mL | 0.5650 mL | 1.4126 mL | |
| 25 mM | 0.0452 mL | 0.2260 mL | 0.4520 mL | 1.1300 mL | |
| 30 mM | 0.0377 mL | 0.1883 mL | 0.3767 mL | 0.9417 mL | |
| 40 mM | 0.0283 mL | 0.1413 mL | 0.2825 mL | 0.7063 mL | |
| 50 mM | 0.0226 mL | 0.1130 mL | 0.2260 mL | 0.5650 mL | |
| DMSO | 60 mM | 0.0188 mL | 0.0942 mL | 0.1883 mL | 0.4709 mL |
| 80 mM | 0.0141 mL | 0.0706 mL | 0.1413 mL | 0.3531 mL | |
| 100 mM | 0.0113 mL | 0.0565 mL | 0.1130 mL | 0.2825 mL |
Bis-PEG13-NHS ester Related Classifications
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