2. Antibody-drug Conjugate/ADC Related PROTAC
  3. ADC Linker PROTAC Linkers
  4. DBCO-PEG4-DBCO

DBCO-PEG4-DBCO 

Cat. No.: HY-130346 Purity: 95.26%
COA Handling Instructions

DBCO-PEG4-DBCO is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. DBCO-PEG4-DBCO is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

For research use only. We do not sell to patients.

DBCO-PEG4-DBCO Chemical Structure

DBCO-PEG4-DBCO Chemical Structure

CAS No. : 2182601-68-7

Size Price Stock Quantity
5 mg USD 65 In-stock
10 mg USD 105 In-stock
25 mg USD 180 In-stock
50 mg   Get quote  
100 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

DBCO-PEG4-DBCO Related Antibodies

Top Publications Citing Use of Products

View All ADC Linker Isoform Specific Products:

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Cleavable Non-cleavable Acid Cleavable Disulfide Cleavable Protease Cleavable Glycosidase Cleavable Phosphatase Cleavable

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PEGs Alkyl-Chain Alkyl/ether

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

DBCO-PEG4-DBCO is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. DBCO-PEG4-DBCO is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

IC50 & Target[1]

Cleavable

 

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

DBCO-PEG4-DBCO Related Antibodies
Molecular Weight

810.93

Appearance

Solid

Formula

C48H50N4O8
CAS No.
SMILES

O=C(NCCC(N1C2=CC=CC=C2C#CC3=CC=CC=C3C1)=O)CCOCCOCCOCCOCCC(NCCC(N4C5=CC=CC=C5C#CC6=CC=CC=C6C4)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (123.32 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.2332 mL 6.1658 mL 12.3315 mL
5 mM 0.2466 mL 1.2332 mL 2.4663 mL
10 mM 0.1233 mL 0.6166 mL 1.2332 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (3.08 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 2.5 mg/mL (3.08 mM); Suspended solution; Need ultrasonic

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (3.08 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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DBCO-PEG4-DBCO Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

DBCO-PEG4-DBCO2182601-68-7ADC LinkerPROTAC LinkersAntibody-drug conjugates linkernon-cleavableADCantibody-drugconjugatesInhibitorinhibitorinhibit

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DBCO-PEG4-DBCO
Cat. No.:
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