1. Antibody-drug Conjugate/ADC Related
  2. ADC Linker
  3. Mal-amide-PEG8-Val-Ala-PAB-PNP

Mal-amide-PEG8-Val-Ala-PAB-PNP 

Cat. No.: HY-148425 Purity: 99.60%
COA Handling Instructions

Mal-amide-PEG8-Val-Ala-PAB-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

For research use only. We do not sell to patients.

Mal-amide-PEG8-Val-Ala-PAB-PNP Chemical Structure

Mal-amide-PEG8-Val-Ala-PAB-PNP Chemical Structure

CAS No. : 2210247-59-7

Size Price Stock Quantity
25 mg USD 720 In-stock
50 mg USD 1200 In-stock
100 mg USD 2000 In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Mal-amide-PEG8-Val-Ala-PAB-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

Molecular Weight

1033.08

Formula

C48H68N6O19

CAS No.
Appearance

Viscous Liquid

Color

Colorless to light yellow

SMILES

O=C(CCOCCOCCOCCOCCOCCOCCOCCOCCNC(CCN1C(C=CC1=O)=O)=O)N[C@@H](C(C)C)C(N[C@@H](C)C(NC2=CC=C(C=C2)COC(OC3=CC=C(C=C3)[N+]([O-])=O)=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (96.80 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9680 mL 4.8399 mL 9.6798 mL
5 mM 0.1936 mL 0.9680 mL 1.9360 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.60%

References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.9680 mL 4.8399 mL 9.6798 mL 24.1995 mL
5 mM 0.1936 mL 0.9680 mL 1.9360 mL 4.8399 mL
10 mM 0.0968 mL 0.4840 mL 0.9680 mL 2.4199 mL
15 mM 0.0645 mL 0.3227 mL 0.6453 mL 1.6133 mL
20 mM 0.0484 mL 0.2420 mL 0.4840 mL 1.2100 mL
25 mM 0.0387 mL 0.1936 mL 0.3872 mL 0.9680 mL
30 mM 0.0323 mL 0.1613 mL 0.3227 mL 0.8066 mL
40 mM 0.0242 mL 0.1210 mL 0.2420 mL 0.6050 mL
50 mM 0.0194 mL 0.0968 mL 0.1936 mL 0.4840 mL
60 mM 0.0161 mL 0.0807 mL 0.1613 mL 0.4033 mL
80 mM 0.0121 mL 0.0605 mL 0.1210 mL 0.3025 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Mal-amide-PEG8-Val-Ala-PAB-PNP Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Mal-amide-PEG8-Val-Ala-PAB-PNP
Cat. No.:
HY-148425
Quantity:
MCE Japan Authorized Agent: