1. Antibody-drug Conjugate/ADC Related
    PROTAC
  2. ADC Linker
    PROTAC Linker
  3. m-PEG6-Amine

m-PEG6-Amine 

Cat. No.: HY-130408
Handling Instructions

m-PEG6-Amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. m-PEG6-Amine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

For research use only. We do not sell to patients.

m-PEG6-Amine Chemical Structure

m-PEG6-Amine Chemical Structure

CAS No. : 184357-46-8

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Description

m-PEG6-Amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. m-PEG6-Amine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

IC50 & Target[1][2]

Cleavable

 

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

295.37

Formula

C₁₃H₂₉NO₆

CAS No.

184357-46-8

SMILES

COCCOCCOCCOCCOCCOCCN

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

m-PEG6-AmineADC LinkerPROTAC LinkerAntibody-drug conjugates linkerPEGPROTAClinkerE3ubiquitinligaseproteinnon-cleavableADCantibody-drugconjugatesInhibitorinhibitorinhibit

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Product Name:
m-PEG6-Amine
Cat. No.:
HY-130408
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