1. Antibody-drug Conjugate/ADC Related
  2. ADC Linker
  3. Fmoc-Gly-Gly-Phe-OtBu

Fmoc-Gly-Gly-Phe-OtBu 

Cat. No.: HY-44234 Purity: 99.80% ee.: 99.49%
Handling Instructions

Fmoc-Gly-Gly-Phe-OtBu is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

For research use only. We do not sell to patients.

Fmoc-Gly-Gly-Phe-OtBu Chemical Structure

Fmoc-Gly-Gly-Phe-OtBu Chemical Structure

CAS No. : 236426-37-2

Size Price Stock Quantity
5 mg USD 450 In-stock
Estimated Time of Arrival: December 31
10 mg USD 750 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1350 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2250 In-stock
Estimated Time of Arrival: December 31
100 mg USD 3350 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Fmoc-Gly-Gly-Phe-OtBu:

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Description

Fmoc-Gly-Gly-Phe-OtBu is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

IC50 & Target[1]

Cleavable

 

Molecular Weight

557.64

Formula

C₃₂H₃₅N₃O₆

CAS No.

236426-37-2

SMILES

O=C(OC(C)(C)C)[[email protected]](CC1=CC=CC=C1)NC(CNC(CNC(OCC2C3=C(C4=C2C=CC=C4)C=CC=C3)=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 200 mg/mL (358.65 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7933 mL 8.9664 mL 17.9327 mL
5 mM 0.3587 mL 1.7933 mL 3.5865 mL
10 mM 0.1793 mL 0.8966 mL 1.7933 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 5 mg/mL (8.97 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 5 mg/mL (8.97 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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  • Molarity Calculator

  • Dilution Calculator

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Fmoc-Gly-Gly-Phe-OtBuADC LinkerAntibody-drug conjugates linkerInhibitorinhibitorinhibit

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Product name:
Fmoc-Gly-Gly-Phe-OtBu
Cat. No.:
HY-44234
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