Lys(MMT)-PAB-oxydiacetamide-PEG8-N3

Name: Lys(MMT)-PAB-oxydiacetamide-PEG8-N3
Brand: MedChemExpress
SKU: HY-131157
Rating: 4.5 (0 reviews)

Cat. No.: HY-131157 Purity: 95.05%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

Lys(MMT)-PAB-oxydiacetamide-PEG8-N3 is a cleavable antibody agent conjugate linker used in the synthesis of antibody-drug conjugates (ADCs). Lys(MMT)-PAB-oxydiacetamide-PEG8-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

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Lys(MMT)-PAB-oxydiacetamide-PEG8-N3 화학구조

CAS No. : 1224601-12-0

사이즈	재고	수량
5 mg	해외재고보유	Estimated Time of Arrival: December 31
10 mg	해외재고보유	Estimated Time of Arrival: December 31
25 mg	해외재고보유	Estimated Time of Arrival: December 31
50 mg	해외재고보유	Estimated Time of Arrival: December 31
100 mg	해외재고보유	Estimated Time of Arrival: December 31
250 mg	해외재고보유	Estimated Time of Arrival: December 31
500 mg	견적 받기
1 g	견적 받기

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This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 1 Customer Validation

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Biological Activity
순도&문서
References
고객리뷰

제품 설명

Lys(MMT)-PAB-oxydiacetamide-PEG8-N3 is a cleavable antibody agent conjugate linker used in the synthesis of antibody-drug conjugates (ADCs)^[1]. Lys(MMT)-PAB-oxydiacetamide-PEG8-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

분자량

1060.24

화학식

C₅₅H₇₇N₇O₁₄

CAS No.

1224601-12-0

Appearance

Oil

Color

Light yellow to yellow

SMILES

O=C(NC1=CC=C(CO)C=C1)[C@@H](NC(COCC(NCCOCCOCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-])=O)=O)CCCCNC(C2=CC=CC=C2)(C3=CC=C(OC)C=C3)C4=CC=CC=C4

선적

Room temperature in continental US; may vary elsewhere.

보관

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

용액&용해도

In Vitro:

DMSO : 100 mg/mL (94.32 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.9432 mL	4.7159 mL	9.4318 mL
5 mM	0.1886 mL	0.9432 mL	1.8864 mL
10 mM	0.0943 mL	0.4716 mL	0.9432 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

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Calculation results:

Working solution concentration: mg/mL

순도&문서

Purity: 95.16%

Select Batch:

Data Sheet (273 KB) SDS (252 KB)

COA (252 KB) HNMR (313 KB) LCMS (97 KB)

Handling Instructions (2659 KB)

References

[1]. Serengulam V. Govindan, et al. EFFICACY OF ANTI-HLA-DR ANTIBODY DRUG CONJUGATE IMMU-140 (hL243-CL2A-SN-38) IN HLA-DR POSITIVE CANCERS. Patent US20170360770.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	0.9432 mL	4.7159 mL	9.4318 mL	23.5796 mL
	5 mM	0.1886 mL	0.9432 mL	1.8864 mL	4.7159 mL
	10 mM	0.0943 mL	0.4716 mL	0.9432 mL	2.3580 mL
	15 mM	0.0629 mL	0.3144 mL	0.6288 mL	1.5720 mL
	20 mM	0.0472 mL	0.2358 mL	0.4716 mL	1.1790 mL
	25 mM	0.0377 mL	0.1886 mL	0.3773 mL	0.9432 mL
	30 mM	0.0314 mL	0.1572 mL	0.3144 mL	0.7860 mL
	40 mM	0.0236 mL	0.1179 mL	0.2358 mL	0.5895 mL
	50 mM	0.0189 mL	0.0943 mL	0.1886 mL	0.4716 mL
	60 mM	0.0157 mL	0.0786 mL	0.1572 mL	0.3930 mL
	80 mM	0.0118 mL	0.0589 mL	0.1179 mL	0.2947 mL