1. PROTAC
    Antibody-drug Conjugate/ADC Related
  2. PROTAC Linker
    ADC Linker
  3. N-Succinimidyl 3-(Bromoacetamido)propionate

N-Succinimidyl 3-(Bromoacetamido)propionate (Synonyms: 3-(2-Bromoacetamido)propanoic acid NHS ester)

Cat. No.: HY-141385
Handling Instructions

N-Succinimidyl 3-(Bromoacetamido)propionate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-Succinimidyl 3-(Bromoacetamido)propionate is also a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

For research use only. We do not sell to patients.

N-Succinimidyl 3-(Bromoacetamido)propionate Chemical Structure

N-Succinimidyl 3-(Bromoacetamido)propionate Chemical Structure

CAS No. : 57159-62-3

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Description

N-Succinimidyl 3-(Bromoacetamido)propionate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N-Succinimidyl 3-(Bromoacetamido)propionate is also a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2].

IC50 & Target

PEGs

 

Alkyl/ether

 

Cleavable

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2].

Molecular Weight

307.10

Formula

C₉H₁₁BrN₂O₅

CAS No.

57159-62-3

SMILES

O=C(ON1C(CCC1=O)=O)CCNC(CBr)=O

Shipping

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

N-Succinimidyl 3-(Bromoacetamido)propionate3-(2-Bromoacetamido)propanoic acid NHS esterPROTAC LinkerADC LinkerAntibody-drug conjugates linkerInhibitorinhibitorinhibit

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Product name:
N-Succinimidyl 3-(Bromoacetamido)propionate
Cat. No.:
HY-141385
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