Azido-PEG(4)-Val-Cit-PAB-PNP
Based on 1 Customer Validation
Azido-PEG(4)-Val-Cit-PAB-PNP is a cleavable peptide ADC linker. Azido-PEG(4)-Val-Cit-PAB-PNP is a click chemistry reagent containing an azide group. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
For research use only. We do not sell to patients.
- Purity: 98.05%
- CAS No.: 1869126-60-2
- Formula: C36H51N9O13
- Molecular Weight:817.84
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Biological Activity
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1869126-60-2
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Appearance Solid
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Molecular Weight 817.84
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Formula C36H51N9O13
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Color White to off-white
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SMILES
[N-]=[N+]=NCCOCCOCCOCCOCCC(N[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=O)C(NC1=CC=C(C=C1)COC(OC2=CC=C(C=C2)[N+]([O-])=O)=O)=O)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 100 mg/mL (122.27 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (241 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.2227 mL | 6.1137 mL | 12.2273 mL | 30.5683 mL |
| 5 mM | 0.2445 mL | 1.2227 mL | 2.4455 mL | 6.1137 mL | |
| 10 mM | 0.1223 mL | 0.6114 mL | 1.2227 mL | 3.0568 mL | |
| 15 mM | 0.0815 mL | 0.4076 mL | 0.8152 mL | 2.0379 mL | |
| 20 mM | 0.0611 mL | 0.3057 mL | 0.6114 mL | 1.5284 mL | |
| 25 mM | 0.0489 mL | 0.2445 mL | 0.4891 mL | 1.2227 mL | |
| 30 mM | 0.0408 mL | 0.2038 mL | 0.4076 mL | 1.0189 mL | |
| 40 mM | 0.0306 mL | 0.1528 mL | 0.3057 mL | 0.7642 mL | |
| 50 mM | 0.0245 mL | 0.1223 mL | 0.2445 mL | 0.6114 mL | |
| 60 mM | 0.0204 mL | 0.1019 mL | 0.2038 mL | 0.5095 mL | |
| 80 mM | 0.0153 mL | 0.0764 mL | 0.1528 mL | 0.3821 mL | |
| 100 mM | 0.0122 mL | 0.0611 mL | 0.1223 mL | 0.3057 mL |