Ethyl azetidine-3-carboxylate hydrochloride
Based on 1 Customer Validation
Ethyl azetidine-3-carboxylate hydrochloride is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Ethyl azetidine-3-carboxylate hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[2]
For research use only. We do not sell to patients.
- Purity : 98.0%
- CAS No.: 405090-31-5
- Formula: C6H12ClNO2
- Molecular Weight:165.62
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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HY-40152
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(R)-Azetidine-2-carboxylic acid -
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1-N-Boc-3-hydroxyazetidine -
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1-Cbz-3-Hydroxyazetidine -
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1-Cbz-azetidine-3-carboxylic acid -
HY-40144
Azetidin-3-ol hydrochloride -
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Fmoc-azetidine-3-carboxylic acid -
HY-16438
RRx-001 -
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L-Azetidine-2-carboxylic acid -
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tert-Butyl 3-oxoazetidine-1-carboxylate -
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Azetidine-2-carboxylic acid
All PROTAC Linkers Isoforms
More
Biological Activity
Description
IC50 & Target
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Non-cleavable Linker |
In Vitro
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 405090-31-5
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Appearance Solid
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Molecular Weight 165.62
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Formula C6H12ClNO2
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Color White to off-white
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SMILES
O=C(C1CNC1)OCC.[H]Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Purity & Documentation
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Data Sheet (265 KB)
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SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Ethyl azetidine-3-carboxylate hydrochloride Related Classifications
HY-W052600 Related Classifications
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