1. Antibody-drug Conjugate/ADC Related
  2. ADC Linker
  3. Fmoc-Gly3-Val-Cit-PAB

Fmoc-Gly3-Val-Cit-PAB 

Cat. No.: HY-136106
Handling Instructions

Fmoc-Gly3-Val-Cit-PAB is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

For research use only. We do not sell to patients.

Fmoc-Gly3-Val-Cit-PAB Chemical Structure

Fmoc-Gly3-Val-Cit-PAB Chemical Structure

Size Price Stock Quantity
100 mg USD 380 In-stock
Estimated Time of Arrival: December 31
500 mg USD 1100 In-stock
Estimated Time of Arrival: December 31
1 g   Get quote  
5 g   Get quote  

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Description

Fmoc-Gly3-Val-Cit-PAB is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

IC50 & Target

Cleavable

 

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

772.85

Formula

C₃₉H₄₈N₈O₉

SMILES

OCC(C=C1)=CC=C1NC([[email protected]](CCCNC(N)=O)NC([[email protected]](C(C)C)NC(CNC(CNC(CNC(OCC2C3=C(C4=C2C=CC=C4)C=CC=C3)=O)=O)=O)=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (129.39 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.2939 mL 6.4696 mL 12.9391 mL
5 mM 0.2588 mL 1.2939 mL 2.5878 mL
10 mM 0.1294 mL 0.6470 mL 1.2939 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 2.5 mg/mL (3.23 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 2.5 mg/mL (3.23 mM); Suspended solution; Need ultrasonic

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (3.23 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Fmoc-Gly3-Val-Cit-PABADC LinkerAntibody-drug conjugates linkerInhibitorinhibitorinhibit

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Product Name:
Fmoc-Gly3-Val-Cit-PAB
Cat. No.:
HY-136106
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