1. Antibody-drug Conjugate/ADC Related
    PROTAC
  2. ADC Linker
    PROTAC Linker
  3. Bis-PEG2-PFP ester

Bis-PEG2-PFP ester 

Cat. No.: HY-112560
Handling Instructions

Bis-PEG2-PFP ester is also a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Bis-PEG2-PFP ester is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

Bis-PEG2-PFP ester Chemical Structure

Bis-PEG2-PFP ester Chemical Structure

CAS No. : 1314378-18-1

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Description

Bis-PEG2-PFP ester is also a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Bis-PEG2-PFP ester is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[2].

IC50 & Target

Non-cleavable

 

PEGs

 

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].

Molecular Weight

538.29

Formula

C₂₀H₁₂F₁₀O₆

CAS No.

1314378-18-1

SMILES

O=C(OC1=C(F)C(F)=C(F)C(F)=C1F)CCOCCOCCC(OC2=C(F)C(F)=C(F)C(F)=C2F)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Bis-PEG2-PFP esterADC LinkerPROTAC LinkerAntibody-drug conjugates linkerInhibitorinhibitorinhibit

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Bis-PEG2-PFP ester
Cat. No.:
HY-112560
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