1. Antibody-drug Conjugate/ADC Related
    PROTAC
  2. ADC Linker
    PROTAC Linker
  3. DBCO-NHCO-PEG4-NH-Boc

DBCO-NHCO-PEG4-NH-Boc 

Cat. No.: HY-126884
Handling Instructions

DBCO-NHCO-PEG4-NH-Boc is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. DBCO-NHCO-PEG4-NH-Boc is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

For research use only. We do not sell to patients.

DBCO-NHCO-PEG4-NH-Boc Chemical Structure

DBCO-NHCO-PEG4-NH-Boc Chemical Structure

CAS No. : 1255942-12-1

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Description

DBCO-NHCO-PEG4-NH-Boc is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. DBCO-NHCO-PEG4-NH-Boc is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

IC50 & Target[1]

Cleavable

 

PEGs

 

Alkyl/ether

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

623.74

Formula

C₃₄H₄₅N₃O₈

CAS No.

1255942-12-1

SMILES

O=C(OC(C)(C)C)NCCOCCOCCOCCOCCC(NCCC(N1C2=CC=CC=C2C#CC3=CC=CC=C3C1)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

DBCO-NHCO-PEG4-NH-BocADC LinkerPROTAC LinkerAntibody-drug conjugates linkernon-cleavableADCantibody-drugconjugatesInhibitorinhibitorinhibit

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Product Name:
DBCO-NHCO-PEG4-NH-Boc
Cat. No.:
HY-126884
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